M.Sc. (Semester II) (CBCS) Examination Mar/Apr-2018
Biotechnology
MOLECULAR MEDICINE
wateriI
Time: 2½ Hours
Max. Marks: 70
Instructions: Section-I compulsory. Answer any four questions from section-II. All question carry equal marks. Draw neat and labeled diagrams wherever necessary.
Section I
Q.1

Rewrite the sentence after choosing the correct answer from the given:-
07
The gene of haemoglobin is located on chromosome number
11
12
16
18
is the study of inherited genetic differences in drug metabolic pathway which can affect individual responses to drugs.
Pharmacology
Genetics
Pharmacogenetics
Pharmacy
gene is mutated is cystic fibrosis.
CFTR
Actin
Cadherin
Fibrin
Nerve tangles in Alzheimer's disease are caused due to protein.
Ameloid beta
Tau protein
Sigma
Delta
In DNA fingerprinting repeated sequences of DNA is used.
Variable number of tandem repeats
Verified number of tandem repeat
Versatile number of transverse repeat
Variable number of transverse repeat
Stem cell exhibits properties.
Only potency
Potency and self renewable
Potency and non renewable
Only self-renewable
MHC Antigen in mouse is known as
HLA
H-2
ASB
HSB

Define the following terms.
07
Potency
In-vivo gene therapy
Positional cloning
Pharmacogenetics
HLA
Amelyoid plaques
Lead optimization
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SLR-UE-92
Section II
Q.2
Answer any four of the following:- Write a note on hemoglobinopathies and explain diseases related to hemoglobin gene mutation.
14
Q.3
Write a note on therapeutic applications of stem cells.
14
Q.4
Explain in detail steps involved in drug discovery and its design.
14
Q.5
Answer any Two of the following:
14
Give an account on Huntinston's disease.
Explain different nature and sources of drug.
Explain in brief human genome project.
Q.6
Write short notes on any Two of the following:
14
Give difference between adult and embryonic stem cells.
Explain non viral methods of gene transfer.
Give and account of DNA fingerprinting and its applications.