M.Sc. (Semester II) (CBCS) Examination Nov/Dec-2018
Biotechnology
MOLECULAR MEDICINE
Time: 2½ Hours Max. Marks: 70
Instructions: All questions of Section I is compulsory.
Answer any four questions from Section II.
All questions carry equal marks.
Draw neat and labeled diagrams wherever necessary.
SECTION I
Q.1 Rewrite the sentences by choosing correct answer from given
alternatives:
07
Mutation in BTK gene leads to condition known as
Phenylketonuria Haemoglobinopathies
Agammaglobulinemia Marfan syndrome
is defined as compound that demonstrates the desired
biological activity on molecular target.
Lead Genome
Mercury Iron
is X linked recessive disease.
DMD CFTR
BTK Marfan
Stem cell exhibits properties.
Only potency Potency and self renewable
Potency and non renewable Only self-renewable
The human gene of haemoglobin is located on chromosome
number
11 12
16 18
Hematopoietic stem cells are
Pluripotent Totipoten
Unipotent Oligopotent
PAH gene is mutated in
Phenylketoneuria Chagas disease
Alzheimer's Cystic fibrosis
Define the terms:- 07
Totipotency
Recombination
Microarray
Lead optimization
Magic bullets
Down's syndrome
Functional cloning
Page 2 of 2
SLR-VE-78
SECTION II
Answer any four of the following:-
Q.2 Define absorption explain in details factor affecting absorption and add a note on
pharmacogenetics.
14
Q.3 Explain in detail viral and non viral methods of gene transfer. 14
Q.4 Explain in brief properties, types and applications of adult stem cells. 14
Q.5 Answer any two of the following:- 14
Give an account on phenyketonuria
Explain in brief agammaglobelinemia
Give an account on human genome project
Q.6 Write short notes on (any 14
Explain in detail Chorionic villus sampling and its applications
Give a brief account on blood and blood group antigens.
Write a brief on Parkinson's disease.