Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER VI • EXAMINATION WINTER • 2016
Subject Code: 2260002 Date: 21-10-2016
Subject Name: Pharmaceutical Microbiology and Biotechnology II
Time: 02:30 pm 05:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain the scope of microbial genetics in pharmaceuticals.
06

Write a note on mutagenic agents.
05

Differentiate transduction and transformation.
05
Q.2

Write a note on applications of monoclonal antibodies and gene cloning.
06

Write a note on streptokinase.
05

Explain growth promotion test.
05
Q.3

Write a note on importance of analytical microbiology in pharmaceuticals.
06

How do you carried out sterility testing for Iodex and sulphacetamide sodium eye drops.
05

Write a note on microbiological assay of cyanocobalamine as per I.P.
05
Q.4

Describe the method of preparation, standardization and storage of BCG.
06

Classify immunity and immunological preparations in detail.
05

Enlist antigen-antibody interactions.write in detail any one.
05
Q.5

Enlist different diagnostic tests involved with immunological principle. Write a note on any one.
06

Differentiate vaccine and sera.
05

Write a note on whole human blood and its storage.
05
Q. 6

Draw neat and labeled diagram of ideal fermentor with role of each part.
06

List out the requirements for ideal plasma substitutes.
05

How the organisms for fermentation are isolated, cultivated, screened and preserve?
05
Q.7

Give the flow sheet of Penicillin production, isolation and recovery by fermentation.
06

Discuss the importance of different parameters for fermentation process.
05

What are standard organism required for production of streptomycin, tetracycline, vitamin B12, citric acid and Riboflavin?
05