Exam Details
| Subject | pharmaceutical chemistry-ix (medicinal chemistry-iii) | |
| Paper | ||
| Exam / Course | b.pharm | |
| Department | ||
| Organization | Gujarat Technological University | |
| Position | ||
| Exam Date | April, 2016 | |
| City, State | gujarat, ahmedabad |
Question Paper
Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
BPHARM SEMESTER VII • EXAMINATION WINTER • 2016
Subject code: 2270003 Date: 21-11-2016
Subject Name: Pharmaceutical Chemistry IX (Medicinal Chemistry III)
Time: 10:30 am 01:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
What are β-lactam antibiotics? Discuss carbapenams.
06
Discuss the following terms: Fanconi's Syndrome, Gray Baby Syndrome
05
Discuss the SAR of tetracyclines with appropriate examples. Discuss epimerization in this class of antibiotics.
05
Q.2
What are aminoglycosides? Why are they called so? Discuss the SAR with relevant examples.
06
Give the scheme of synthesis of Chloramphenicol and discuss its SAR.
05
Give the basis of selective toxicity of sulphonamides by its MOA. Write a note on synergism of sulphonamides and discuss its SAR.
05
Q.3
Describe the SAR of Quinolones with suitable examples.
06
Discuss the scheme of synthesis of- Ofloxacin Trimethoprim
05
Show which biochemical difference of fungi is exploited in anti fungal therapy and write a note on the Azoles with apt examples.
05
Q.4
Write a note on drugs used in treatment of infections caused by Mycobacterium
06
Write a note on drugs used in treatment of helmintic infections and discuss synthesis of Albendazole
05
Write a note on Anti Viral drug therapy with examples of drugs used.
05
Q.5
Classify anti malarial drugs with correct examples and write a note on combination therapy in malaria.
06
Write a note on the natural products used as antineoplastic agents.
05
Classify anti neoplastic alkylating agents with relevant examples. Discuss synthesis of 5-Fluorouracil.
05
Q. 6
Write a note on solid phase technique in combinatorial experiments.
06
What is Lead optimization and discuss the role of isosteres.
05
What is QSAR? Discuss the role of hydrophobicity in it.
05
Q.7
What is the Hanch analysis? Discuss
06
Write a note on Molecular modeling strategies and applications
05
Discuss the topliss decision tree and the Free Wilson approach to QSAR.
05
GUJARAT TECHNOLOGICAL UNIVERSITY
BPHARM SEMESTER VII • EXAMINATION WINTER • 2016
Subject code: 2270003 Date: 21-11-2016
Subject Name: Pharmaceutical Chemistry IX (Medicinal Chemistry III)
Time: 10:30 am 01:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
What are β-lactam antibiotics? Discuss carbapenams.
06
Discuss the following terms: Fanconi's Syndrome, Gray Baby Syndrome
05
Discuss the SAR of tetracyclines with appropriate examples. Discuss epimerization in this class of antibiotics.
05
Q.2
What are aminoglycosides? Why are they called so? Discuss the SAR with relevant examples.
06
Give the scheme of synthesis of Chloramphenicol and discuss its SAR.
05
Give the basis of selective toxicity of sulphonamides by its MOA. Write a note on synergism of sulphonamides and discuss its SAR.
05
Q.3
Describe the SAR of Quinolones with suitable examples.
06
Discuss the scheme of synthesis of- Ofloxacin Trimethoprim
05
Show which biochemical difference of fungi is exploited in anti fungal therapy and write a note on the Azoles with apt examples.
05
Q.4
Write a note on drugs used in treatment of infections caused by Mycobacterium
06
Write a note on drugs used in treatment of helmintic infections and discuss synthesis of Albendazole
05
Write a note on Anti Viral drug therapy with examples of drugs used.
05
Q.5
Classify anti malarial drugs with correct examples and write a note on combination therapy in malaria.
06
Write a note on the natural products used as antineoplastic agents.
05
Classify anti neoplastic alkylating agents with relevant examples. Discuss synthesis of 5-Fluorouracil.
05
Q. 6
Write a note on solid phase technique in combinatorial experiments.
06
What is Lead optimization and discuss the role of isosteres.
05
What is QSAR? Discuss the role of hydrophobicity in it.
05
Q.7
What is the Hanch analysis? Discuss
06
Write a note on Molecular modeling strategies and applications
05
Discuss the topliss decision tree and the Free Wilson approach to QSAR.
05
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- agronomy and forestry of medicinal plants
- anatomy physiology & health education -ii
- anatomy, physiology and health education (aphe)
- applied mathematics (biostatistics)
- basic computer applications
- basic concepts of pharmacology and clinical pharmacy practice
- basics of computer applications
- bioavailability & therapeutic drug monitoring
- bioavailability and therapeutic drug monitoring
- biochemistry
- clinical pharmacy ii
- clinical pharmacy-i
- commerce of herbs and phytoconstitutents
- computer applications in drug discovery
- current advances in novel drug delivery systems
- cyber security
- disaster management
- dispensing pharmacy i
- dispensing pharmacy i and drug store management
- dispensing pharmacy ii and pharma industrial management
- dosage form design –i
- dosage form design- i
- dosage form design- ii
- dosage form design-i
- dosage form design-ii
- drug approval process
- environmental studies
- environmental toxicology and green audit
- food analysis
- forensic pharmacy
- forensic pharmacy-i
- genetic engineering and gene therapy
- green chemistry
- health education and community health
- herbal cosmetics
- hospital and community pharmacy
- hospital management and medical tourism
- hospital pharmacy, community pharmacy & forensic pharmacy
- hospital pharmacy, community pharmacy and dispensing pharmacy-ii
- human anatomy physiology
- human anatomy physiology and health education-ii
- human anatomy physiology-ii
- human anatomy, physiology and health education - i
- innovations in conventional drug delivery system
- instrumental and process validation
- intellectual property rights and patents
- medical writing and coding
- medicinal biochemistry
- nutraceuticals
- pathophysiology
- pharmaceutical analysis ii
- pharmaceutical analysis iii
- pharmaceutical analysis iv
- pharmaceutical analysis-i
- pharmaceutical analysis-ii
- pharmaceutical analysis-iv
- pharmaceutical chemistry – ii
- pharmaceutical chemistry – vi (organic chemistry – ii)
- pharmaceutical chemistry –viii (medicinal chemistry - ii)
- pharmaceutical chemistry iii
- pharmaceutical chemistry iv
- pharmaceutical chemistry vii
- pharmaceutical chemistry-i
- pharmaceutical chemistry-i (inorganic chemistry)
- pharmaceutical chemistry-ii (physical chemistry)
- pharmaceutical chemistry-iii (biochemistry – i)
- pharmaceutical chemistry-iv (organic chemistry-i)
- pharmaceutical chemistry-ix (medicinal chemistry-iii)
- pharmaceutical chemistry-v
- pharmaceutical chemistry-v (biochemistry-ii)
- pharmaceutical chemistry-vi (medicinal)
- pharmaceutical chemistry-vii
- pharmaceutical chemistry-viii
- pharmaceutical chemistry-x
- pharmaceutical chemistry-x (medicinal chemistry-iii)
- pharmaceutical engineering
- pharmaceutical engineering-ii
- pharmaceutical inorganic chemistry
- pharmaceutical marketing management
- pharmaceutical microbiology - i
- pharmaceutical microbiology & biotechnology i
- pharmaceutical microbiology &biotechnology- ii
- pharmaceutical microbiology and biotechnology - ii
- pharmaceutical organic chemistry
- pharmaceutical technology - i
- pharmaceutical technology – i
- pharmaceutical technology- ii
- pharmaceutical technology-i
- pharmaceutical technology-ii
- pharmaceutics-i
- pharmaceutics-ii
- pharmaceutivcal chemistry ix
- pharmacognosy iii
- pharmacognosy iv
- pharmacognosy vi
- pharmacognosy vii
- pharmacognosy vii (herbal formulations & complimentary therapies)
- pharmacognosy-i
- pharmacognosy-ii
- pharmacognosy-iii
- pharmacognosy-iv
- pharmacognosy-v
- pharmacognosy-v (plant bio technology)
- pharmacognosy-vi
- pharmacology -iii
- pharmacology & pharmacotherapeutics-ii
- pharmacology and pharmacotherapeutics - i
- pharmacology and pharmacotherapeutics - iii
- pharmacology and pharmacotherapeutics-iv
- pharmacology-i
- pharmacology-ii
- pharmacovigilance
- pharmacy practice
- physical pharmaceutics-ii
- physical pharmacy
- quality by design (qbd) and process analytical technology (pat)
- regulatory aspects of food and neutraceuticals
- remedial mathematics
- unit operation - i
- unit operation - ii