Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm SEMESTER VII • EXAMINATION WINTER 2016
Subject Code: 270003 Date: 21/11/2016
Subject Name: PHARMACEUTICAL CHEMISTRY-IX (MEDICINAL CHEMISTRY)
Time: 10.30 am to 01.30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1

Write SAR of Sulfonamides.
06

Write mechanism of action uses and side effect of Fluoroquinolones.
05

Write IUPAC name and Synthesis of following (Any two)
1. Trimethoprim 2. Ciprofloxacin 3. Sulfacetamide
05
Q.2

Write detail SAR of Cefalosprins.
06

Write Mechanism of action, uses, side effect and degradation of penicillins.
05

What detail notes on macrolide antibiotics.
05
Q.3

Explain SAR of tetracyclines in detail.
06

Briefly explain aminoglycoside antibiotics.
05

Write IUPAC name and Synthesis of following (Any two)
1. Chloramphenicol 2. Ethambutol 3. Primaquine
05
Q.4

What are antitubercular agents Briefly explain drugs used in Multi-Drug Resistance Tuberculosis (MDR-TB).
06

Write mechanism of action, uses and side effect of antifungal agents
05

Write IUPAC name and Synthesis of following (Any two)
1. Fluconazole 2. Metronidazole 3. Mebendazole
05
Q.5

Explain briefly drugs used as anti-malarial agents.
06

Write detail note on drugs used in treatment of HIV infection
05

Write short notes on antithyroid agents.
05
Q. 6

Write detail notes on alkylating anticancer agents.
06

Briefly explain immune suppressive agents.
05

Write IUPAC name and Synthesis of following (Any two)
1. Chlorambucil 2. Methotrexate 3. Metformin
05
Q.7

What are steroid? Write Nomenclature and stereochemistry of steroids in detail.
06

Write SAR of glucocorticoids
05

Briefly explain oral hypoglycemic agents.
05