Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER-VII • EXAMINATION SUMMER 2017
Subject Code: 2270003 Date: 03/05/2017
Subject Name: PHARMACEUTICAL CHEMISTRY-IX (MEDICINAL CHEMISTRY-III)
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1

Briefly explain SAR of Fluoroquinolones.
06

Write mechanism of action, uses and side effect of sulfonamide in detail.
05

Write IUPAC name and Synthesis of following (Any two)
1. Sulphamethoxazole 2. Metronidazole 3. Ciprofloxacin
05
Q.2

Write detail SAR of Penicillins.
06

Write short notes on cephalosporin antibiotic.
05

What detail notes on macrolide antibiotics and aminoglycoside antibiotics.
05
Q.3

Write SAR of tetracyclines in detail.
06

Briefly explain degradation of penicillin and tetracycline antibiotics.
05

Write IUPAC name and Synthesis of following (Any two)
1. Chloramphenicol
2. Isoniazid
3. Chloroquine
05
Q.4

What are antitubercular agents Briefly explain first line antitubercular agents.
06

Write mechanism of action, uses and side effect of antifungal agents with minimum one structure in each class.
05

Write IUPAC name and Synthesis of following (Any two)
1. Clotrimazole
2. Albendazole
3. Amantadine
05
Q.5

Explain life cycle of Malarial parasite and drug acting on each stage of life cycle. Write brief note on quinolines as antimalarial agents.
06

Write short notes on Anthelmintics.
05

Explain Antiviral agents in detail.
05
Q. 6

Write detail notes on alkylating anticancer agents.
06

Write short notes on Combinatorial chemistry.
05

Write IUPAC name and Synthesis of following (Any two)
1. Cyclophosphamide
2. Tamoxifen
3. Fluorouracil
05
Q.7

Write detail notes on Molecular Modeling.
06

What is lead molecules? Briefly explain lead optimization techniques.
05

Explain in detail Hansch Linear Free Energy Relationship model in drug design.
05