Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
BPHARM SEMESTER II • EXAMINATION WINTER • 2016
Subject code: 2220001 Date: 13-01-2017
Subject Name: Physical Pharmacy
Time: 02:30 pm 05:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Write in brief on nature of the intra- and intermolecular forces involved in stabilizing molecular and physical structures.
06

Discuss two component system containing phenol water liquid phases.
05

Write a note on liquid crystals.
05
Q.2

Classify various viscometers. Describe a viscometer to find out viscosity of non-Newtonian fluids with labeled diagram.
06

Define and differentiate: Plastic and Pseudo-plastic flow.
05

What are applications of rheology in pharmaceutical industry?
05
Q.3

Give general principles of solubility.
06

Write a note on spreading co-efficient.
05

Explain solubility of solid in liquid.
05
Q.4

Describe methods of calculation of HLB value.
06

Explain any one method for measurement of surface and interfacial tensions.
05

Write a brief note on electric properties of interfaces.
05
Q.5

Define complexation. Discuss methods of analysis of complexes.
06

Which factors affects complexation and protein binding? Discuss in brief.
05

Describe cyclodextrin complexes including their application in pharmacy.
05
Q. 6

Discuss factors affecting powder flow.
06

Enumerate derived properties of powder. How they affect pharmaceutical product manufacturing?
05

Which are the methods used for particle size determination? Explain optical microscopy method.
05
Q.7

Differentiate hydrophilic and lipophilic colloids.
06

Write in brief on properties of colloids.
05

Write a note on factors affecting stability of suspension.
05