Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER- 8 EXAMINATION SUMMER -2019
Subject Code: 280001 Date: 04-05-2019
Subject Name: Dosage Form Design- II
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Enumerate various approaches for gastro retentive drug delivery system. Describe formulation and evaluation of any one.
06

Discuss Cube route dissolution equation with respect to drug release from modified release dosage forms.
05

Discuss erosion-controlled drug delivery system.
05
Q.2

Comment on following with reasons:
1. Osmotically controlled formulation system releases drug through zero order rate.
2. Liposomes are more stable as compared to niosomes.
06

Describe formulation and evaluation of transdermal drug delivery systems.
05

Discuss the impact of biological factors in designing modified release oral dosage forms
05
Q.3

Describe various formulation strategies for preparing liposomes. Describe sample formulation for liposome in brief.
06

Explain drug interaction. Discuss ADME drug interactions with suitable examples.
05

Enlist different pharmacokinetic models. What is compartment model? Mention advantages and disadvantages of the same.
05
Q.4

Discuss one compartment open model i.v. infusion model and discuss the effect of loading i.v. injection dose
06

Describe in detail the formulation and evaluation of Hydrogels.
05

Describe with example preparation and evaluation of parenteral suspension.
05
Q.5

What is maintenance dose and loading dose for modified release drug delivery system. Write in brief the method to find them.
06

Write a note on osmotic ocular inserts. Mention the components of each part.
05

Explain the significance of Renal clearance and dosage regimen.
05
Q. 6

What are rationales for colon targeting? Name different approaches for colon targeting and discuss any one with example.
06

What is extraction ratio? Define clearance, total body clearance and organ clearance.
05

Enlist the methods for determination of absorption rate constant and explain any one in detail.
05
Q.7

Write in brief the formulation and evaluation of microspheres.
06

Explain non-linear pharmacokinetics using Michaelis Menten equation.
05

Classify methods for formulation of nanoparticles. Discuss any one in detail.
05