Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. SEMESTER- VIII• EXAMINATION WINTER-2017
Subject Code: 280001 Date: 02-11-2017
Subject Name: Dosage Form Design-II
Time: 02:30 pm to 05:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Give the difference between sustained and controlled drug delivery system. Describe the evaluation of oral controlled drug delivery system.
06

Describe the advantage, disadvantage and limitation of sustained release formulation.
05

Describe loading and maintenance dose in controlled release formulation with equations.
05
Q.2

Explain Pharmacokinetic. Explain typical plasma level time curve affect single oral dose.
06

Describe Wegner-Nelson method for determination of adsorption rate constant.
05

Explain in detail compartmental and non compartmental approach.
05
Q.3

Mention the method of evaluation of microspheres in detail.
06

Classify the polymer used in preparation of matrix tablet. Give two name of each class.
05

What is Nano particle. Give any one method in detail for preparation of Nano particle.
05
Q.4

Explain renal clearence. Describe graphical method for determination of renal clearance.
06

Write a note on osmotic ocular inserts. Explain parts of ocular inserts.
05

Explain non linear pharmacokinetic using michaeles menten equation.
05
Q.5

Describe the ideal requirements for Sustained release formulation. Explain lag time, burst effect and reservoir system with respect to controlled release formulation.
06

Explain Pharmacokinetic and Pharmacodynamic parameters to be consider for designing modified drug delivery system.
05

Write a note on Hydrogel.
05
Q. 6

Discuss Mechanism of release of drug from controlled release drug delivery system.
06

Explain the Pharmaceutical approach to develop colonic drug delivery system in brief.
05

Explain Volume of distribution and distribution coefficient.
05
Q.7

What criteria are necessary for selection of drug as a candidate for controlled release formulation. Explain each in brief.
06

Define clinical pharmacokinetic and explain dosage adjustment in patient with renal failure.
05

Discuss the formulation of parenteral emulsion and suspension.
05