Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 280001 Date: 15/11/2018
Subject Name: Dosage Form Design- II
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss in brief the Hixon and Crowell's cube root dissolution equation for controlled release dosage forms.
06

Explain biological and physicochemical factors, which are responsible for designing oral sustained release drug delivery system.
05

Explain loading dose and maintenance dose used in controlled release formulation.
05
Q.2

Explain lag time, burst effect and reservoir systems with respect to control release formulations.
06

Explain apparent volume of distribution. State its significance.
05

Describe preparation and evaluation of parenteral suspension.
05
Q.3

What is non-linear pharmacokinetic? Describe the equation that governs the non-linear Pharmacokinetics.
06

Write a note on osmotic ocular inserts. Mention the components of each part.
05

Give an account of approaches for designing of gastro retentive dosage forms.
05
Q.4

Discuss one compartment open model i.v. infusion model and discuss the effect of loading i.v. injection dose. Describe the derivation of various pharmacokinetic parameters for the model.
06

Classify liposomes? Why are considered versatile carriers for parenteral drug delivery.
05

Explain the significance of renal clearance and dosage regimen.
05
Q.5

What properties are required for the drug to be a candidate for transdermal drug deliverysystem? Explain formulation of transdermal drug delivery system.
06

Define clinical pharmacokinetics and explain dosage adjustment in patients with renal failure.
05

Write a note on Hydrogel.
05
Q.6

Define 'Drug interaction'. Discuss the factors that contribute to drug interaction. Give suitable examples.
06

Write a note on: Wagner-Nelson method used to estimate absorption rate constant
05

Define clearance, total body clearance and organ clearance. What is extraction ratio?
05
Q.7

Explain pharmacokinetic and pharmacodynamics parameters, which are considered in design of, modified drug delivery systems?
06

Enlist different approaches for formulation of colon targeted drug delivery system and explain any one of them.
05

Write a note on evaluation parameters of microsphere.
05