Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2280003 Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry X (Medicinal Chemistry III)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Give the method of synthesis of
Warfarin Metformin Carbimazole
06

Write informative note on Anti platelet Agents
05

What is obesity? Write a note on antiobesity drugs.
05
Q.2

Discuss the SAR among Cardiac glycosides.
06

Write short note on immunomodulators.
05

Give the method of synthesis of Lignocaine Atenolol
05
Q.3

Give the method of synthesis of
Clofibrate Ethacrinic acid Glimipride
06

Discuss the SAR among
Estrogens Dihydropyridnes
05

Write short notes on Thrombolytic agents.
05
Q.4

Define and classify Diuretic Agents. Discuss the SAR among Progestins and Androgens.
06

Write detail note on Cardio tonic Agents.
05

Write down notes on Coagulants and Anticoagulants.
05
Q.5

What are the causes of hypertension Write a note on β-blockers.
06

Define and classify Hypoglycemic Agents.
05

Give SAR of ACE inhibitors.
05
Q. 6

What is Diabetes Classify antidiabetics with examples and give their mechanism of action.
06

Discuss the SAR among
Thiazide Diuretics Sulfamoyl Benzoic acid derivatives.
05

Discuss detail about Plasma expanders
05
Q.7

Explain in detail the nomenclature and stereochemistry of Steroidal Compounds.
06

Discuss the SAR among HMG CoA Reductase inhibitors.
05

Give the method of synthesis of Acetazolamide Captopril
05