Exam Details

Subject pharmaceutical chemistry-x (medicinal chemistry-iii)
Paper
Exam / Course b.pharm
Department
Organization Gujarat Technological University
Position
Exam Date November, 2018
City, State gujarat, ahmedabad


Question Paper

Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 280003 Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry-X (Medical Chemistry)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define and classify diuretics. Write a note on loop diuretics.
06

Sketch the important steps in synthesis of Ethacrinic acid Furosemide.
05

Explain in detail the steric and electronic parameters used in QSAR.
05
Q.2

Write the structure, its ring system, mechanism of action, metabolism and side effects of any one catecholamine depletory used as antihypertensive.
06

Sketch the important steps in synthesis of Lignocaine Flecainide.
05

Write a note on arterial and venous vasodilators.
05
Q.3

Define molecular modeling and write a note on application of Computer Aided Drug Design technique.
06

Outline the SAR of cardiotonics.
05

Define QSAR and write a note on Hansch Linear Free Energy Relationship model.
05
Q.4

Define antihypertensive agents with its classification and write a note on calcium channel blockers.
06

Sketch the important steps in synthesis of Captopril Clofibrate.
05

Explain the SAR of 4-Dihydro pyridines.
05
Q.5

What is Free Wilson Mathematical Model? Explain it.
06

Enlist the centrally acting adrenergic drugs with structures used as antihypertensives.
05

Enumerate different methods of lead discovery. Write a short note on optimization of lead.
05
Q. 6

Write a note on plasma volume expanders and antiobesity drugs.
06

What is the mechanism of action and SAR of ACE inhibitors?
05

Define cardiotonic drugs. Write classification with structures.
05
Q.7

Discuss the mechanism of action and SAR of 5-Sulfamoyl benzoic acid derivatives.
06

Write a note on combinatorial chemistry.
05

Write in detail giving examples the role of antiplatelet agents.
05



Subjects

  • agronomy and forestry of medicinal plants
  • anatomy physiology & health education -ii
  • anatomy, physiology and health education (aphe)
  • applied mathematics (biostatistics)
  • basic computer applications
  • basic concepts of pharmacology and clinical pharmacy practice
  • basics of computer applications
  • bioavailability & therapeutic drug monitoring
  • bioavailability and therapeutic drug monitoring
  • biochemistry
  • clinical pharmacy ii
  • clinical pharmacy-i
  • commerce of herbs and phytoconstitutents
  • computer applications in drug discovery
  • current advances in novel drug delivery systems
  • cyber security
  • disaster management
  • dispensing pharmacy i
  • dispensing pharmacy i and drug store management
  • dispensing pharmacy ii and pharma industrial management
  • dosage form design –i
  • dosage form design- i
  • dosage form design- ii
  • dosage form design-i
  • dosage form design-ii
  • drug approval process
  • environmental studies
  • environmental toxicology and green audit
  • food analysis
  • forensic pharmacy
  • forensic pharmacy-i
  • genetic engineering and gene therapy
  • green chemistry
  • health education and community health
  • herbal cosmetics
  • hospital and community pharmacy
  • hospital management and medical tourism
  • hospital pharmacy, community pharmacy & forensic pharmacy
  • hospital pharmacy, community pharmacy and dispensing pharmacy-ii
  • human anatomy physiology
  • human anatomy physiology and health education-ii
  • human anatomy physiology-ii
  • human anatomy, physiology and health education - i
  • innovations in conventional drug delivery system
  • instrumental and process validation
  • intellectual property rights and patents
  • medical writing and coding
  • medicinal biochemistry
  • nutraceuticals
  • pathophysiology
  • pharmaceutical analysis ii
  • pharmaceutical analysis iii
  • pharmaceutical analysis iv
  • pharmaceutical analysis-i
  • pharmaceutical analysis-ii
  • pharmaceutical analysis-iv
  • pharmaceutical chemistry – ii
  • pharmaceutical chemistry – vi (organic chemistry – ii)
  • pharmaceutical chemistry –viii (medicinal chemistry - ii)
  • pharmaceutical chemistry iii
  • pharmaceutical chemistry iv
  • pharmaceutical chemistry vii
  • pharmaceutical chemistry-i
  • pharmaceutical chemistry-i (inorganic chemistry)
  • pharmaceutical chemistry-ii (physical chemistry)
  • pharmaceutical chemistry-iii (biochemistry – i)
  • pharmaceutical chemistry-iv (organic chemistry-i)
  • pharmaceutical chemistry-ix (medicinal chemistry-iii)
  • pharmaceutical chemistry-v
  • pharmaceutical chemistry-v (biochemistry-ii)
  • pharmaceutical chemistry-vi (medicinal)
  • pharmaceutical chemistry-vii
  • pharmaceutical chemistry-viii
  • pharmaceutical chemistry-x
  • pharmaceutical chemistry-x (medicinal chemistry-iii)
  • pharmaceutical engineering
  • pharmaceutical engineering-ii
  • pharmaceutical inorganic chemistry
  • pharmaceutical marketing management
  • pharmaceutical microbiology - i
  • pharmaceutical microbiology & biotechnology i
  • pharmaceutical microbiology &biotechnology- ii
  • pharmaceutical microbiology and biotechnology - ii
  • pharmaceutical organic chemistry
  • pharmaceutical technology - i
  • pharmaceutical technology – i
  • pharmaceutical technology- ii
  • pharmaceutical technology-i
  • pharmaceutical technology-ii
  • pharmaceutics-i
  • pharmaceutics-ii
  • pharmaceutivcal chemistry ix
  • pharmacognosy iii
  • pharmacognosy iv
  • pharmacognosy vi
  • pharmacognosy vii
  • pharmacognosy vii (herbal formulations & complimentary therapies)
  • pharmacognosy-i
  • pharmacognosy-ii
  • pharmacognosy-iii
  • pharmacognosy-iv
  • pharmacognosy-v
  • pharmacognosy-v (plant bio technology)
  • pharmacognosy-vi
  • pharmacology -iii
  • pharmacology & pharmacotherapeutics-ii
  • pharmacology and pharmacotherapeutics - i
  • pharmacology and pharmacotherapeutics - iii
  • pharmacology and pharmacotherapeutics-iv
  • pharmacology-i
  • pharmacology-ii
  • pharmacovigilance
  • pharmacy practice
  • physical pharmaceutics-ii
  • physical pharmacy
  • quality by design (qbd) and process analytical technology (pat)
  • regulatory aspects of food and neutraceuticals
  • remedial mathematics
  • unit operation - i
  • unit operation - ii