FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Main) Examination
Subject Medicinal Chemistry II
Time 3 hours Max. Marks 70
Note: Answer all questions. All questions carry equal marks.
1 Classify narcotic analgesics with examples and explain their mechanism of
action. 4+1
Outline the synthesis and mention the uses and IUPAC name of following
drugs.
Lidocaine ii) Pethidine iii) Diclofenac sodium 3 x 3 9
OR
Write the SAR of pethidine derivatives and Indole acetic acid derivatives. 3+3
Write a note on NSAID's 8
2 Write a note on alkylating agents used as antineoplastic agents. 8
Classify sulphonamides according to their chemical structure with examples. 6
OR
Classify Penicillins and write the synthesis of any one penicillin drug. 8
Write a note on Quinolone antibacterials. 5
3 Write the definition, classification and uses of antifungal agents. 7+7
Write the synthesis of any one drug of
Antitubercular ii) Antifungal category
OR
Write the life cycle of malarial parasite and describe in detail about the
antimalarial agents. 14
4 Define and classify sedatives and hyphotics with examples. 1+5
Write a note on anticonvulsants. 8
OR
Write a note on parkinsonism and the drugs used for its treatment. 7
Write a note on Anxiolytics. 7
5 Write any two essential amino acids and explain their functional role. 6
Write the structure, preparation and uses of Vitamin E and B1. 4+4
OR
Write the chemical structure, preparation and uses of any two Vitamins from
water soluble vitamins. 4+4
Describe briefly about development of protein drugs. 6