FACULTY OF PHARMACY
B. Pharmacy 4/4 I-Semester (Suppl.) Examination, April 2016
Subject Medicinal Chemistry II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Define and classify local anaesthetics with suitable examples.
Describe the SAR of paraamnio benzoic acid derivatives used as Local
anaesthetics.
Write the IUPAc name and synthesis of Lidocaine and Ibuprofen.
OR
What are analgesics Write the different mechanisms of analgesic action and
classify narcotic analgesics.
Write the structure and synthesis of
Pethidine Naloxone
2 Classify anti-neoplastic agents and write the synthesis of following drugs.
Methotrexate sulphamethoxazole Chloramphenicol
OR
Write the mode of action of sulphonanides and classify the sulphonamides based on
chemical structures.
Write the SAR of penicillins.
3 Classify antitubercular agents and write the mode of action, write the IUPAC name and
synthesis of following:
INH Chloroquine Metronidazole
OR
Describe in detail about the following:
4-aminoquinolines used as antimalarials
Antifungal agents
Antiprotozoal drugs
4 Write in detail about the following class of drugs and their applications.
Barbiturates
Benzodiazepines
Phenothiazines
OR
Write the chemical structure of any one drug belongs to the following category and
mention the name of ring present and write the IUPAC name of drug.
Anticonvulsants
Antipsychotics
Sedative and Hypnotics
Write a note on General anaesthetics.
5 Draw the chemical structure, preparation and storage of any two water soluble
and any two fat soluble vitamins.
Write in brief about biochemical role of Vitamin A.
OR
Write a note on Development of protein drugs.
Write the biochemical role of any three vitamins.