FACULTY OF PHARMACY
B. Pharmacy 4/4 Year I Semester (Main) Examination
Subject: Biopharmaceutics Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 Write about
Gastric emptying 8
ii) Intestinal transit 6
OR
Explain
Passive diffusion 7
ii) Influence of compression force on absorption 4
iii) Role of surfactants in absorption 3
2 Explain various physiological barriers to drug distribution. 9
Write a note on volume of distribution. 4
OR
Write the significance of protein drug binding. 9
Explain perfusion rate limited distribution. 5
3 Describe various factors affecting drug biotransformation. 8
Write about
Glomerular filtration 3
ii) Salivary excretion 3
OR
Explain
Biliary excretion of drugs 8
ii) Active secretion 3
iii) Glucouronidation reaction 3
4 Enlist and explain the significance of various pharmacokinetic parameters. 6
What are mixed order processes? Give examples. 4
t1/2 2.5 hrs Vd 55 lts. Calculate clearance. 4
OR
Draw a typical plasma concentration time profile graph for a drug administered
orally showing pharmacokinetic and pharmacodynamic parameters. Write their
significance 8
Write a note on non-compartmental analysis. 6
5 IV bolus dose 184 mg. Assume one compartment kinetics. The equation of the
curve that best fits the data is c 141e-0.026t c is in mg/lt, t is in hrs. Calculate
Biological half life AUC from zero to infinite time Vd
Clearance Plasma drug concentration after 6 hrs 14
OR
How do you estimate absorption rate constant using Wagner Nelson method. 8
Drug is given by iv infusion. Half life is 22 hrs. Vd 15.7 lts. Desired steady state
concentration is 0.0002 g/ml. Assuming one compartment kinetics, calculate
time required to reach 90% of Css infusion rate to achieve desired steady state
and loading dose to attain steady state rapidly. 6