FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Suppl.) Examination, April 2017
Subject: Bio-Pharmaceutics Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 With neat labeled diagrams explain in detail various theories of drug dissolution.
What do you mean by biopharmaceutics and give its importance. 10+4
OR
List out various factors affecting the drug absorption. Explain in detail about
formulation factors affecting the drug absorption. 14
2 Discuss the role of protein binding in drug distribution. What components of the
plasma proteins are important in binding of drugs. 14
OR
Describe in detail perfusion limited drug distribution. Give factors affecting drug
distribution. 10
How the organ size and perfusion rate influence the drug distribution. 4
3 What are conjugation reactions? Give examples for each type of conjugation
reaction. 14
OR
Explain the factors influencing renal excretion of drugs. 10
Explain briefly about enterohepatic circulation. 4
4 Define bioavailability. Explain about AUC, Cmax, Tmax, MEC and MTC. Discuss
different methods used for determination of AUC of blood level-time curve of a drug. 14
OR
Define apparent volume of distribution. How it is determined? 10
Discuss briefly about hepatic clearance. 4
5 What are the compartment models? Derive an expression for calculating various
pharmacokinetic parameters for a drug administered by intravenous bolus
administration. 14
OR
A single intravenous injection of 5 mg Kg of drug A is given to a 50 year subject
(weight 80 Kg). the following plasma concentrations are collected. Assume that it
follows one compartment open model. Calculate all possible pharmacokinetic
parameters. 10
Time
0.1 0.5 1 8 16 24 48
Plasma concentration
1.142 1.0627 0.9712 0.2755 0.0653 0.0155 0.0002
A penicillin solution containing 300 has a half life of 8 days in plasma. What
will be the concentration in 7 days? 4