FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Suppl.) Examination, April 2018
Subject: Bio-Pharmaceutics Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain patient related factors affecting absorption. 7
Explain pH partition hypothesis. 7
OR
Explain dosage form factors affecting the absorption. 7
Write a note on passive diffusion. 7
2 Explain the factors affecting protein drug binding. 7
Explain about tissue binding of drugs. 7
OR
Explain permeability rate limited and perfusion rate limited drug distribution. 9
Write a note on volume of distribution. 5
3 Explain the factors affecting the biotransformation of drugs. 14
OR
Write about non renal routes of excretion of drugs. 7
Explain in detail about enterohepatic circulation of drugs. 7
4 Explain the methods of dose adjustment in patients with renal failure. 7
Explain the plasma concentration time profile. 7
OR
Explain about different methods of determination of AUC. 7
Explain the significance of drug interactions in combination therapy. 7
5 Explain the method of residuals for calculation of absorption rate constant in one
compartment open model. 7
A drug has a half life of 6 hrs. If it has a volume of distribution of 72 litres in an 85 kg
individual. What is its charance? If its clearance is decreased by 50% due to renal
failure what will be its new half life? (Assume Vd remains constant). 7
OR
A single intravenous injection of 5 mg/kg of drug A is given to a 50 year subject
(weight 80 kg). The following plasma concentrations are collected. Assume that it
follows one compartment open model. Calculate all possible pharmacokinetic
parameters. 14
d

Time 0.1 0.5 1 8 16 24 48
Plasma Concentration
1.142 1.0627 0.9712 0.2755 0.90653 0.0155 0.0002