FACULTY OF PHARMACY
Pharm D. YDC) III Year (Main) Examination, September October 2017
Subject Medicinal Chemistry
Time 3 hours Max. Marks 70
Note: Answer all questions from Part-A. Answer any FIVE questions from Part-B.
PART A (10 x 2 20 Marks)
1. Write a note on bioprecursor prodrug. 2
2. Give structure, mechanism of action and use of any one antifungal antibiotic. 2
3. What are anticoagulants? Write structure, mechanism of action of any one drug. 2
4. Write structures, IUPAC name of any two antiseptics. 2
5. Classify antihelmentnic drugs with one example for each class. 2
6. List out any four antitubercular drugs. Write structure, mechanism of action of any
one drug. 2
7. What are diagnostic agents? Write the structures of any two. 2
8. Write a note on antiscabies agents. 2
9. Write the structure of any two anti-tubercular agents. 2
10.Give popular brand name for the following drugs. 2
Ciprofloxacin ii) Glimeperide iii) Furosemide
iv) Amoxicillin and clavulinic acid
PART B x 10 50 Marks)
11.a) What is Prodrug? Write their classification based on the functional groups. 4
Discuss SAR of Quinolones as antibacterials. 3
Give synthesis, mechanism of action of Norfloxacin. 3
12. Write a note on the following with special reference to their chemistry
Tetracyclines ii) β-blockers as antihypertensives 2 x 5 10
13. Outline the synthesis, mechanism of action, uses of the following 4 x 2.5 10
Isoniazid ii) Tinidazole iii) Sulphamethoxazole iv) Pyrimethamine
14. Write a note on the following
Semisynthetic Penicillins ii) Thiazide diuretics iii) Antianginal agents
15.a) Classify oral hypoglycaemic agents with one example for each class. 2.5
Outline synthesis, mechanism of action of the following
Glibenclamide ii) Furosemide iii) Clofibrate 3 x 2.5 7.5
16.a) Write the structures, mechanism of action, therapeutic uses of any four
anticancer agents from different class. 6
Write a note on antiviral drugs. 4
17.a) Classify antihypertensives with one example for each class. 2
Write synthesis, mechanism of action, uses of the following 2 x 3 6
Clonidine ii) Diltiazem
Write structure, mechanism of action, uses of Artether. 2
18. Write a note on Oral contraceptives ii) Antithyroid drugs
iii) Class I antiarrhythmic agents