FACULTY OF PHARMACY
Pharm. D YDC) III-Year (Main) Examination, July 2017
Subject Medicinal Chemistry
Time 3 Hours Max. Marks: 70
Note: Answer all questions from Part A and answer any five questions from Part-B.
PART A (10 x 2 20 Marks)
1 What are various parameter used in QSAR?
2 Give two structure of Loop diuretics.
3 What is application of combinational chemistry?
4 What are diagnostic Agents? Give one example with an application?
5 What is the action of anti ineffective drugs?
6 Some drug containing an ester group are inactive invitro but once the drug absorbed invivo.
what term is used for such drug post drug predrug Metabolite pro-drug
7 Define antithrombolytic.
8 Give popular brand name of following drugs.
Cefadroxil Tinadazole ofloxacin melformin
9 Sketch the structure and medicinal use of chloramphenicol.
10 Write the mechanism of action of anti-angina agent.
PART B x 10 50 Marks)
11 Write a note Antiscables and antipediculars agent.
Write the SAR of tetracycline.
12 Write the synthesis, mechanism of action of following drug cefadroxil Isomazy
ampicillin metronidazole
13 Classify sulphonamides. Give one example with structure for each class.
Outline the synthesis of Enalapris Mechlor ethamin
14 Write the SAR of angio-tension II antagonist.
Write a note on antithyroid agents.
15 Give a brief account on steroidal hormones.
Write the synthesis of any two drugs belonging to class anti-malarial.
16 Classify diuretics with examples. Write the synthesis of acetozolmide.
Write a note on macrocide agent.
17 Classify antihyper lidemic agents and write the synthesis any one of them.
Outline the synthesis of Tolbutamide and metformin.
18 Write a note on local infective agents.
Classify the pro-drug and enlist the ideal property.