FACULTY OF PHARMACY
Pharm D. YDC) III Year (Instant) Examination, January 2018
Subject Medicinal Chemistry
Time 3 hours Max. Marks 70
Note: Answer all questions from Part-A. Answer any FIVE questions from
Part-B.
PART A (10 x 2 20 Marks)
1 What is combinational chemistry? Write its application in the drug discovery. 2
2 Classify antimalarials with one example for each class. 2
3 Give structures, IUPAC name of any two sulphonamides used as antibacterials. 2
4 Write a note on β-lactamase inhibitors. 2
5 Write structure, mechanism of action of any one coumarin derivative as
anticoagulant. 2
6 Write a note on angiotensin-II antagonists. 2
7 Write structure, mechanism of action of any two drugs belonging to
sulphonylureas as oral hypoglycaemic agents. 2
8 Write the structures of any two diagnostic agents in evaluating kidney function. 2
9 Exemplify any four steroidal anti-inflammatory drugs. Write structures of any
two. 2
10 Give popular brand name for the following 2
Cephelexin ii) Chloroquin iii) Metformin iv) Ketoconazole
PART B x 10 50 Marks)
11 Define QSAR and explain about Hansch and Free-Wilson analysis. 6
Write a note on loop diuretics. 4
12 Write the applications of prodrug with suitable examples. 4
Outline the synthesis, mechanism of action, uses of the following 2 x 3 6
Ciprofloxacin ii) Metronidazole
13 Give the synthesis, mechanism of action, uses of the following 2 x 3 6
Chloroquin ii) Ketoconazole
Write a note on aminoglycoside antibiotics. 4
14 Classify anthelmentic drugs with one example for each class. 2
Outline the synthesis, mechanism of action, uses of the following
Isoniazid ii) Albendazole iii) Methotrexate 2.5+2.5+3
15 Classify diuretics with one example for each class. 2
Write a note on Calcium channel blockers 5
ii) Bile acid sequestrants as antihyperlipidemic agents 3
16 Write a note on anti anginal agents
ii) Biguanides as oral hypoglycaemic agents
iii) Androgens and anabolic agents
17 Classify alkylating agents with one example for each class. Write the
synthesis, mechanism of action of any one drug. 4
Outline the synthesis, mechanism of action, uses of the following
Captopril ii) Triamterene 2x3=6
18 Write a note on Antithyroid drugs ii) Anti AIDS agents
iii) Local anti infective agents