FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Main) Examination,
February 2018
Subject: Advanced Medicinal Chemistry
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Give an account on various types of drug targets.
Discuss types of Receptors and their activation mechanism.
2 Discuss the various approaches used in the design of analogues from Lead
Compound.
Give an account on pro-moieties for various functional groups in prodrug
design.
3 Classify antihypertensive drugs with example.
Explain how the chirality of a drug molecule influences it's pharmacokinetic
properties
4 Define drug resistance and discuss the mechanisms of antibiotic drug resistance.
Classify anti convulsants with examples and discuss the SAR of barbiturates.
5 Give an account on enzyme inhibitors in medicine and basic research.
Explain about Non-covalently binding enzyme inhibitors.
6 Define peptidomimetics and discuss the advantages of them over peptide drugs.
Explain the various approaches involved in peptidomimetic drug design.
7 Discuss the chemistry of prostaglandins and leukotrienes.
Explain the concept of bio-isosterism.
8 Write a short note on
ACE inhibitors
HIV protease inhibitors