FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Suppl.) Examination,
August 2018
Subject: Advanced Medicinal Chemistry
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Discuss about various stages involved in the drug discovery.
Explain the theories of drug receptor interactions.
2 Define prodrug and discuss the applications of prodrugs with suitable examples.
Discuss the strategies to overcome the drug resistance to antibiotics.
3 Give the classification of H1 and H2 histamine receptor antagonists with suitable
examples.
Discuss how chirality of drug molecule influences the pharmacological
action?
4 Give the classification of enzyme inhibitors with suitable examples.
Discuss the rational design of reversible enzyme inhibitors.
5 Define peptidomimetics and discuss the various types of peptidomimetics.
Explain the various approaches used in peptide modifications in peptidomimetics
design.
6 Classify antineoplastic drugs with suitable examples and discuss the mechanism
of action of methotrexate and chlorambucil.
Discuss the chemistry of prostaglandins. Write the structures of therapeutically
useful prostaglandins.
7 Write a note on
Sources for lead identification
Drug receptor interactions
8 What are bio-isosters? Discuss their applications in analogue design.
Write a note on cyclooxygenase inhibitors.