FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I Semester (Main Backlog)
Examination, February 2019
Subject Advanced Medicinal Chemistry
Time 3 hours Max. Marks 75
Note Answer any FIVE questions. All questions carry equal marks.
1 Discuss the concept of rational drug design in new drug discovery.
Write a note on the sources of lead discovery. 9+6
2 Explain the development of resistance to anticancer drugs and underlying
mechanisms.
How does ADME properties are improved through prodrug design? 8+7
3 Give an account on COX-II inhibitors.
Classify adrenergic antagonists and discuss the SAR of B-blockers. 8+7
4 Define drug resistance and discuss the strategies to overcome resistance to
antibiotics.
Classify anti convulsants with examples and discuss the SAR of
Benzodiazepines. 8+7
5 Give an account on rational design of enzyme inhibitors.
Explain about Non-covalently binding enzyme inhibitors. 8+7
6 Write a note on modification of amino acid in peptidomimetic design.
Write a note on manipulation of peptide back bone and incorporation of
conformational constraints in peptidomimetic drug design. 8+7
7 Discuss, how does the stereochemistry of drug influences absorption, distribution
and elimination.
Explain the concept of bio-isosterism. 10+5
8 Write a short note on
ACE inhibitors H2 antihistaminics 8+7