M.Sc. (Semester IV) (CBCS) Examination Oct/Nov-2017
Microbiology
PHARMACEUTICAL MICROBIOLOGY
Day Date: Friday, 24-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Part- Questions No.1 Compulsory.
Attempt any 4 questions from Part II.
Figures to the right indicate full marks.
Answer to the Part I and Part II are to be written in same answer booklet
only.
PART I
Q.1 Choose the correct alternative given in the bracket. 14
The destruction of all micro organisms including spores is called
Sanitation Antisepsis
Sterilization Disinfection
the precursor used for the production of penicillin G.
Sulfate waste liquor Nutrient agar
Corn step agar Phenyl acetic acid.
DNA gyrase.
Penicillin Chloramphenicol
Cefoxitin Tobramycin
a second generation cephalosporin
Cefaclor Ceflazidime
Cepholexin Cefotaxime
A primarily bacteriostatic antibiotic
Chloramphenicol Penicillin
Vancomycin Gentamicin
Macroolide
are not used except for serious infection
inhibits the 50s ribosomal subunit
are bactericidal
are inactivated by beta-lactamases
not semisynthetic penicillin.
Procaine penicillin Ampicillin
Cloxacillin Carbenicillin
An externally administered chemical substance are called
Antibiotic Disinfectants
Antiseptics Drugs
inhibits nucleic acid synthesis.
Norfloxacillin Chloramphenicol
Penicillin Ampicillin
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SLR-MQ-608
10) In pregnancy safe antibiotic.
Gentamycin Erythromycin
Doxycycline Moxifloxacin
11) Food poisoning is mainly caused by
Corynebacterium diptheriae Clostridium rockfortae
Clostridium tetani Clostridium botulinum
12) The 50s ribosomal subunit is target for ____antibiotics
Macrolide Chloramphenicol
Bactericidal Antifungal
13) Treatment of autoimmune disease
Metabolic control
Use of anti-inflammatory drugs
Use of immunosuppressive drugs
All of these
14) inhibit the incorporation of thymine into macromolecules of
sensitive cells.
Chloramphenicol Pencillin
Rifamycin Ciprofloxacin
PART II
Answer any four questions from the following.
Q.2 What are multivalent subunit vaccines? Discuss in detail new vaccine
technology.
14
Q.3 Give a detailed account of Biosensors and its applications in Pharmaceuticals. 14
Q.4 Explain in detail Microbial contamination and spoilage of pharmaceutical
products with reference to sterile injectibles, non injectibles and ophthalmic
preparation.
14
Q.5 Write in short on any Two of the following: 14
Describe in detail how the antimicrobial agents the targets.
What are Government regulatory practices and policies?
Explain its importance in pharmaceutical industry.
Describe briefly Drugs delivery system gene therapy.
Q.6 Write short notes on any TWO of the following: 14
What is Immobilization? Explain with procedures for pharmaceutical industry.
Describe briefly mode of action of non-antibiotic antimicrobial agents.
Describe in detail action of antibiotics on nucleic acid synthesis.