M.Sc. (Semester IV) (CBCS) Examination Nov/Dec-2018
Microbiology
PHARMACEUTICAL MICROBIOLOGY
Time: 2½ Hours Max. Marks: 70
Instructions: Part Question 1 is compulsory.
Attempt any four questions from part II.
Figures to the right indicate full marks.
Answers to part I and part II are to be written in same answer booklet only.
PART I
Q.1 Rewrite the sentences by choosing correct answer from given alternatives: 14
Acyclovir is a drug.
Antiviral Antifungal
Antialgal Antibacterial
is a second generation cephalosporin.
Ceflazidime Cefaclor
Cepholexin Cefotaxime
is not an antifungal antibiotic.
Fluconazole Ketoconazole
Vancomycin Amphotericin
is designated to kill bacteria but does not kill endospore.
Funhgicide Bactericide
Viricide Sporocide
Hydrogen peroxide, iodine, boric acid, and alcohol are all examples of
common
Antiseptics Antibiotics
Sterilizers Injections
The target of antibiotics is topoisomerase enzyme.
Aminoglycosides Quinolones
Fosfomycins Beta Iactams
A is an injection, that deposits a drug in a localized mass.
Local Spot
Depot None of these
Hepatitis A vaccine is an example of type of vaccine.
DNA Live
Killed Inactivated
concerned with Time at constant temperature required to kill
specific number (around of microbe.
L value Z value
D value S value
10) enzyme is used as "clot blusters" to dissolve clots in the arteries of
heart wall.
Asparginase Streptokinase
Collagenase Glutaminase
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SLR-VP-440
11) The biological indicators in sterilization is
Bacillus thermophilus Bacillus subtilus
Geobacillus stearothermophilus Geobacillus aquaticus
12) Enzyme asparginase have been used in the treatment of
Gaucher's Disease type I Gaucher's Disease type II
Acute Childhood Leukemia Cystic Fibrosis
13) The role of is to protect the integrity and quality of manufactured
product intended for human use.
Good laboratory practices Good human practices
Good record practices Good manufacturing practices
14) use a attenuated form of the germ that causes a disease.
DNA vaccines Live vaccines
Killed vaccines All of above
PART II
Attempt any four questions from Part II
Q.2 Describe in detail Mode of action of non-antibiotics antimicrobial agents. 14
Q.3 Comment on the various sterilization techniques employed for sterilizing the
Pharmaceutical products in industries.
14
Q.4 Describe in detail Microbial contamination and spoilage of pharmaceutical
products with reference to sterile injectibles, non injectibles, and ophthalmic
preparations.
14
Q.5 Write short answer. (Any two) 14
What are Biosensors? Explain its application in pharmaceutical industry.
Describe in detail action of antibiotics on bacterial protein synthesis.
What is drug designing? Briefly describe, the drug designing process.
Q.6 Write short notes on. (Any Two) 14
Explain how the antimicrobial agents reach the targets?
What is Immobilization? Explain application of Immobilization in
pharmaceutical industry.
New vaccine technology.