M.Sc. Microbiology (Semester-IV) (CBCS) Examination, 2017
Pharmaceutical Microbiology
Day Date: Wednesday, 26-04-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions Part Question 1 is compulsory.
Attempt any 4 questions from Part II
Figures to the right indicate full marks.
Answer to the Part I and Part II are to be written
Same answer booklet only.
PART I
Q.1 A Rewrite the sentence by choosing correct alternative from
the following
14
Macrolides have…….
Enhanced activity at acidic pH
Little activity against legionella
Induce cytochrome p450 enzymes
Half lives which increase in patients with anuria
….. is considered to be bacteriostatic antibiotic.
Penicillin Chloramphenical
Ciprofloxacin Cefoxitin
The effective drug against penicillin resistant bacteria is…..
Chloramphenicol Erythromycins
Augmentin None of these
…… inhibits bacterium cell wall synthesis.
Tetracycline Erythromycins
Penicillin Both a b
During RBC count Blood must be prepared from ……
EDTA blood Citrated blood
Oxalated blood Clotted blood
Food poisoning is mainly caused by…..
Corynobacterium diptheriae
Clostridium rockfortae
Clostridium tetani
Clostridium botulinum
Page 1 of 3
Ribosomal resistance occurs with……
Sulphonamides Penicillin
Macrolides Fluoroquinolones
Generally the most effectively acting antimicrobial substance
is……
Sodium hypochlorite Phenols
Alcohol Sodium bicarbonate
….. can be used safely in pregnancy
Gentamycin Erythromycin
Doxycycline Moxifloxacin
10) Treatment of autoimmune disease includes…….
Metabolic control
Use of anti-inflammatory drugs
Use of immunosuppressive drugs
All of these
11) ……. is described as best secondary metabolite.
Acetic acid produced from the oxidation of ethanol
Ethanol from the fermentation of glucose
Penicillin
Citric acid from the partial oxidation of glucose.
12) …….. agar is used for screening antibiotic producers and
acid producer.
Simmson's Nutrient
Wilkins Sabouraud's
13) Bacillus licheniformis is used for production of…..
Cloxacillin Streptomycin
Penicillin Bacitracin
14) The purification and recovery of the production after
fermentation is called as
Upstream process
Downstream process
Surface fermentation
None of these
PART II
Answer any four questions from the following
Q2 What is new vaccine technology? Discuss various DNA
vaccines, synthetic peptide vaccines, and multivalent subunit
vaccines.
14
Q3 Give a detailed account on Microbial contamination and spoilage
of pharmaceutical products.
14
Page 2 of 3
Q4 Describe in detail sulphonamides and Quinolinone antimicrobial
agents
14
Q5 Write short answers (any two) 14
Explain in detail application of microbial enzymes in
pharmaceuticals
What is Good Laboratory Practices Explain its importance
in pharmaceutical industry.
Describe briefly Drug delivery system in gene therapy.
Q6 Write short notes on any two 14
What is Immobilization? Explain with procedures for
pharmaceutical industry
Define Biosensors, Explain its application in pharmaceutical
industry.
Describe in detail action of antibiotics on bacterial cell wall
synthesis.