M.Sc. (Semester III) (CBCS) Examination Nov/Dec-2018
Microbiology
IMMUNOLOGY AND IMMUNOTECHNOLOGY
Time: 2½ Hours Max. Marks: 70
Instructions: Part Question 1 is compulsory.
Figures to the right indicate full marks.
Attempt any four questions from Part II.
Answer Part I and Part II are to be written in same answer booklet only.
PART I
Q.1 Rewrite the sentences by choosing correct answer from given alternatives: 14
Tumour markers are
Sign of infection
Chemicals that can be detected in the blood
Related to genetics
External growths
is secondary lymphoid organ.
MALT Spleen
Lymph node All of these
Which of the following is the most effective response to a tumour?
Antibodies Cytotoxic T lymphocytes
Macrophages NK cells
Which one of the following is a primary lymphoid organ?
Thymus Lymph nodes
Tonsil Spleen
In a auroimmune disease idiopathic thrombocytopic purpura autoantibodies
are produced against
Platelets WBC
Thyroid hormones RBC
Anti-Nuclear antibodies test can be used for diagnosis of
Rheumatoid arthritis Systemic lupus erythematosus
Multiple myeloma Complement deficiencies
IgM antibody
is the main class of the natural antibodies
is most commonly tetrameric
has the same number of constant domains as of IgG
is weak bacterial agglutinator
Generally antibodies produced against the pathogen are
Monoclonal Polyclonal
Homogenous a b both
Cell mediated immunity protects the body from pathogenic agents.
Intracellular Extracellular
Both a and b None of these
Page 2 of 2
SLR-VP-438
10) Bacteria, neoplastic cell, virus infected cells as well as intracellular parasites
containing cells are destroyed by
T lymphocytes NK cells
B lymphocytes Phagocytes
11) The MHC in mouse called H2 gene complex is located on chromosome no.
in mice.
16 6
14 17
12) Protection against microorganisms inside cells is provided by
C3b Antibody
T-cells C1q
13) Histamine is
Allergen Secondary mediator of anaphylaxis
Atopen Primary mediator of anaphylaxis
14) Cytokines are
Low molecular weight proteins
High molecular weight protein
Low molecular wt carbohydrate
High molecular weight lipoproteins
PART II
Attempt any four questions.
Q.2 Answer the following:- (Any four)
What are Types of lymphocytes?
What is Thymus?
What is role of Macrophage?
What is Phygocytosis?
What is Mucosa associated lymphoid tissue?
08
Write note (Any Two)
Application of immunology in diagnostic medicine
Autoimmunity
TCR
06
Q.3 Answer the following (Any
Structure and function of MHC gene complex in human.
Differential between normal and cancer cell.
Signal transduction by TCR/CD3.
08
Answer the following (Any
Primary and secondary lymphoid organs
Principle and kinetics of antigen antibody reaction.
06
Q.4 Answer the following:- (Any Two)
Use of Anti Nuclear Antibody test for diagnosis o SLE and other
autoimmune diseases.
Evolution of immune system in vertebrates and invertebrates.
Immunodeficiency disorders.
10
Answer the following:- (Any One)
HLA typing.
Diagnosis of cancer by tumour markers.
04
Q.5 Answer the following:- (Any Two) 14
Role of cytokines.
Innate and acquired immunity
Natural killer cells