THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LM 352] MAY 2018 Sub. Code: 2913
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER IV DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code 262913
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Write about the basic considerations of drug design. Add a note on denova drug
design and lead seeking methods.
2. Discuss in detail about receptor polymorphism, dimerisation and its importance in
drug design. Write in detail about various theories of drug receptor interactions.
II. Write notes on: (10 x 6 60)
1. Isosterism and Steric behavior.
2. Vectors used in gene therapy.
3. Prodrug concepts and its applications.
4. Gene mapping.
5. Signal transduction pathway.
6. Applications of molecular pharmacology.
7. Computer aided drug design.
8. Forces involved in drug receptor interactions.
9. Isolation of RNA from yeast.
10. Proteomics and array technology.