MAY 2017 Sub. Code: 2913
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER IV DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code 262913
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Write in detail on combinatorial chemistry. Write the applications of drug
designing.
2. Explain the pharmacodynamic and pharmacokinetics of peptide and protein drugs.
II. Write notes on: (10 x 6 60)
1. Complex events between drug administration and drug action.
2. Explain briefly about electronic parameters used in QSAR.
3. Write the drug designing of pro drugs.
4. Non-viral vectors in gene therapy.
5. Briefly explain the pharmacogenomic approach in drug discovery.
6. Hydrogen bonding and surface actions.
7. Protein isolation using gel electrophoresis.
8. Rational drug design.
9. Structural factors in drug design.
10. Correlative methods and analysis of results.