OCTOBER 2017 Sub. Code: 2913
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER IV DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code 262913
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Write about the protein structure prediction and molecular modeling.
2. Classify Receptors. Explain various theories and forces involved in drug Receptor
interaction.
II. Write notes on: (10 x 6 60)
1. Bio-sensors.
2. Partition co-efficient.
3. Write the importance of chelates in medicine.
4. Viral vectors in Gene therapy.
5. Describe the structure of G-protein coupled receptors.
6. What are Ion channels? Explain how Ion channels act as drug targets.
7. Explain about the identification of a pharmacophore in computer aided drug
design.
8. Oxidation reduction potential.
9. Cell signaling.
10. QSAR parameters related to chemical structure.