OCTOBER 2017 Sub. Code: 2912
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER III BIOLOGICAL STANDARDISATION AND PHARMACOLOGICAL
SCREENING METHODS
Q.P. Code 262912
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain the various animal models employed in the screening of gastric anti-ulcer
activity.
2. Discuss in detail the role of transgenic animal models in pre-clinical research.
II. Write notes on: (10 x 6 60)
1. Guinea pig wheal method.
2. Bio-assay of insulin employing mice.
3. One way ANOVA.
4. Randall Sellito method.
5. Methods employed in anaesthesia of laboratory animals.
6. Maze models for anxiolytic drug screening.
7. Morris water maze test.
8. Any two methods for the screening of skeletal muscle relaxant activity.
9. Heterogenous immuno assay system.
10. Two methods for the screening of sympathomimetic activity using dog as an
experimental animal.