MAY 2017 Sub. Code: 2912
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER III BIOLOGICAL STANDARDISATION AND PHARMACOLOGICAL
SCREENING METHODS
Q.P. Code 262912
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain in detail the CPCSEA guidelines for laboratory animal facility.
2. Discuss in detail the various methods employed in the screening of centrally acting
analgesics.
II. Write notes on: (10 x 6 60)
1. Bioassay of digitalis using rabbit.
2. Irwin's test.
3. Any two animal models used for the screening of antioxidant activity.
4. Maximal electro shock induced seizure model.
5. Screening for anti-fertility activity.
6. Chronic toxicity studies.
7. Different methods employed in the euthanasia of laboratory animals.
8. Carrageenan-induced rat paw oedema model.
9. Homogenous immunoassay system.
10. Chi square test.