THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LN 345] OCTOBER 2018 Sub. Code: 2906
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II PHARMACEUTICAL CHEMISTRY
PAPER III ADVANCED MEDICINAL CHEMISTRY
Q.P. Code 262906
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain elaborately the medicinal chemistry aspects of anti-neoplastic agents with
emphasis to classification, mechanism of action, structure and synthesis of any
two from each class.
2. Discuss in detail about the rational design of non covalently and covalently
binding enzyme inhibitors.
II. Write notes on: (10 x 6 60)
1. Write a brief account on 3D-QSAR studies.
2. Explain in detail about the industrial method of manufacture of paracetamol.
3. Write a note on the types of receptors.
4. Briefly discuss about immune stimulants.
5. Brief out the design of analogs on the basis of alteration of chain branching and
from fragments of lead molecule.
6. Discuss briefly about molecular mechanics in molecular modelling studies.
7. Define pro-drugs and discuss its types and advantages.
8. Discuss the mechanism of gastric acid secretion.
9. Explain briefly the clinically approved prostaglandins.
10. Write a note on the role of enantio selectivity in drug ADME.