MAY 2017 Sub. Code: 2906
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II PHARMACEUTICAL CHEMISTRY
PAPER III ADVANCED MEDICINAL CHEMISTRY
Q.P. Code 262906
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain various strategies utilized in analog design.
2. Explain the types of receptors and various theories involved in drug receptor
interactions.
II. Write notes on: (10 x 6 60)
1. Briefly explain the rationale of prodrug design with the applications.
2. Discuss briefly about the mechanism of action, structure and synthesis of any one
ACE inhibitors.
3. Explain the industrial method of preparation of diphenhydramine.
4. Outline various aspects on irreversible gastric proton pump inhibitors.
5. Briefly discuss about immune stimulants.
6. Outline the medicinal chemistry aspects of anticancer plant drugs.
7. Discuss the electronic parameters involved in QSAR.
8. Write a note on quantum mechanics.
9. Elaborate briefly about covalent enzyme inhibitors.
10. Explain the importance of stereo selectivity in drug action.