OCTOBER 2017 Sub. Code: 2906
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II PHARMACEUTICAL CHEMISTRY
PAPER III ADVANCED MEDICINAL CHEMISTRY
Q.P. Code 262906
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Discuss in detail various techniques and approaches utilized in molecular
modelling studies.
2. Enumerate elaborately the medicinal chemistry aspects of gastric proton pump
inhibitors.
Write a detailed note on the role of chirality in drug action in therapeutic
agents.
II. Write notes on: (10 x 6 60)
1. Explain briefly about types of noncovalent enzyme inhibitors.
2. Discuss on various concepts involved in analog design.
3. Enumerate QSAR study by Free Wilson method and Hansch analysis.
4. Briefly explain various steps involved in the manufacture of sulphamethoxazole.
5. Write a note on calculation of affinity and pharmacophore models.
6. Discuss the medicinal chemistry aspects of newer anti HIV agents with examples.
7. Briefly elaborate the pharmacokinetic and biopharmaceutical aspects prodrug
chemistry.
8. Discuss the mechanism of action and SAR of alkylating agents.
9. Describe briefly on drug receptor interactions.
10. Write a note on immune response.