M.Sc. (Semester III) (CBCS) Examination Nov/Dec-2018
Zoology
MOLECULAR CYTOGENETICS
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Draw diagrams wherever necessary.
Q.1 Choose the correct alternatives and rewrite the sentence:- 14
is an inherited disease of faulty synthesis of hemoglobin.
Thalassemia PKU
Glucoma SCID
is the complete set of chromosomal and extrachromosomal
gene of an organism.
Gene pool Gene bank
Genome Gene library
C-value paradox suggests
colinearity between genome size and complexity of organism
non-colinearity between genome size and complexity of organism.
linkage analysis
number of chromosome
Sex chromosome based dosage compensation in human is brought about
by
inactivation of one X-chromosome in females
inactivation of one X-chromosome in males
hypoactivity of both X-chromosome in females
hyperactivity of autosomes in females.
In addition to the transposase gene, mobile IS element must also carry

an antibiotic resistance gene
inverted terminal repeat sequence
interspersed repeating sequence
terminal genes
In Q-banding, bright bands are composed of DNA rich is
guanine and cytosine cytosine and adenine
thymine and cytosine thymine and adenine
The intervening nucleotide sequences in DNA are called
Exons Codons
Histones Introns
chromosomes appear v-shaped during anaphase.
Metacentric Acrocentric
Telocentric Sub-melacentric
virus has eight segments of RNA as genome.
SV 40 Influenza
Adenovirus HIV
Page 2 of 2
SLR-VS-510
10) An individual with chromosomes compliment 45, XO is known as
syndrome.
Turner Klinefeller
Edwards Down
11) Nucleosome core particle is a of basic histones.
Tetramer Hexamer
Octamer Decamer
12) The end of chromosome are called as
Telomere Chromosome
Chromonemata Centromere
13) is the important check point protein of G1 phase of cell cycle.
pRB p53
Ras Rad51
14) Pseudominance is seen during
Duplication Deletion
Translocation Inversion
Q.2 Answer the following:- (Any four) 08
What is satellite DNA?
Write a note on viral genome.
Define the term chromosome painting.
What is heritable disease?
What is bacteriophage? Give an example
Write a note on (Any two) 06
Application of RFLP in pedigree analysis
Heterochromatin.
Karyotyping
Q.3 Answer the following (Any two) 08
What is the effect of ionizing and non-ionizing radiation on
chromosome?
Explain the vectors used for cDNA library.
Discuss the structure of metaphase chromosome.
Answer the following (Any one) 06
Explain in detail molecular basis of cellular check points.
Discuss in detail human genome analysis.
Q.4 Answer the following (Any two) 10
Write an essay on transposable elements.
Explain the role of methylase, nucleases and restriction endonucleases
in host cell restriction.
Discuss the chromosome banding method and its types.
Answer the following (Any one) 04
Write a note on organellar genome.
Discuss in detail sex determination in Drosophila.
Q.5 Answer the following (Any two) 14
Describe in detail the structural organization of chromosome.
Explain in detail sickle cell anemia.
Discuss in structural alteration in chromosome.