Master of Science II (Organic Chemistry)
Examination: Oct Nov 2016 Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR
SD 183
Wednesday
23/11/2016
02.30 PM
to
05.00 PM
Drugs and Heterocycles
C
XII
Instructions: Answer any five questions.
All questions carry equal marks.
Section-I is compulsory.
Attempt any two questions from Section II
Attempt any two questions from Section III
Total Marks:70
SECTION I
Q.1 Define the terms of following:
Chemotherapy
Bacteriostatic and bactericidal
Antiseptics and Disinfectants
Drugs
Sarcoma
Anti-neoplastic
Anti-hypertensive drugs
14
Predict the product of the following reactions:
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SECTION II
Q.2 What are antibiotic? Explain the synthetic methods, uses and adverse effect of
Ampicillin.
07
What are antipyretics and analgesics? Discuss the synthesis and mechanism of
action of Meperidine.
07
Q.3 How will you synthesize the anti-Inflammatory drugs of following:
Diclofenac
Indomethacin
07
Discuss the synthesis and uses of the following drugs:
Isoniazide
Ethambutol
07
Q.4 What are general and local anaesthetics? Explain the synthesis, mechanism of
action, uses and side effect of Lignocaine.
07
Write notes any two of the following:
Phenobarbitone
Diazepam
Quinidine
07
SECTION III
Q.5 Explain the synthesis of Indole by Fischer and Madelung synthetic methods
and suggest the mechanism.
05
Discuss the synthesis and chemical properties if Thiazoles. 05
Ring opening chemical reactions of oxetanes. 04
Q.6 Discuss the synthesis and chemical reactions of Thiiranes. 05
What are pyrazole? How will you synthesize the pyrazole derivatives from:
3-dicarbonyl compounds and
Chalcones
05
Physical and chemical properties of Benzofuran. 04
Q.7 Write a note on any three of the following: 14
Isoquinoline
Coumarin
Pyridazine
Pyrimidines
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