Exam Details
| Subject | drugs and heterocycles | |
| Paper | ||
| Exam / Course | m.sc. electronic science | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | April, 2018 | |
| City, State | maharashtra, solapur |
Question Paper
M.Sc. (Semester III) (CBCS) Examination Mar/Apr-2018
Organic Chemistry
DRUGS AND HETEROCYCLES
Time:2½ Hours
Max. Marks: 70
Instructions: Attempt in all 5 questions. Section I is compulsory. Attempt any two questions from Section II and any two from Section III Answers to all questions (Section II and III) should be written in the one answer book. All questions carry equal marks. Figures to the right indicate full marks.
SECTION I
Q.1
Define the pharmaceutical terms of the following.
07
Cardiovascular drugs
Anti-neoplastic
AIDS
Histamine
NSAID
Prodrugs
Antiarrhythmic drugs
Predict the product(s) of the following reactions:
SECTION II
Q.2
What are antibiotics? Explain the synthesis and uses of following antibiotics:
07
Ampiciline
Cephalexin
What are anti-tubercular drugs? Explain the synthesis and mechanism of action of following anti-tubercular drugs.
07
Isoniazide
Ethambutol
Q.3
Discuss the various synthesis methods of procaine and mechanism of nerve impulse transmission in action of Local anaesthetics.
07
What are antimalarials? Give the synthesis and mechanism of action of trimethoprim.
07
Q.4
What are analgesic and antipyretic drugs? Discuss the synthesis, applications and adverse effects of the following drugs.
07
Paracetamol
Meperidine
Explain the synthesis, applications and side effects of following anti-Inflammatory drugs (any
07
Dichlorophenac
Indomethacin
Arachidonic acid
SECTION III
Q.5
Explain the synthesis of benzofuran from coumarin. What is the action of following on benzofuran:
05
Cl2/ CS2
DMF/ POCl3
Ac2O
Explain the cyclization of open chain to aziridine ring is stereo specific. What is the reaction of following on aziridine:
05
HCl
CH3COCl
Vinyl cyanide
Synthesis of coumarin and chromones.
04
Q.6
Explain synthesis of oxazole derivatives from acyl-amino ketones, esters and amides with suitable example.
05
Write various synthesis methods of quinoline and isoquinolines.
05
Explain Fisher- Indole synthesis with mechanism.
04
Q.7
Write notes on any three of the following:-
14
Pyridazine
Purines
Quinoxalines
Pyrazoles
Organic Chemistry
DRUGS AND HETEROCYCLES
Time:2½ Hours
Max. Marks: 70
Instructions: Attempt in all 5 questions. Section I is compulsory. Attempt any two questions from Section II and any two from Section III Answers to all questions (Section II and III) should be written in the one answer book. All questions carry equal marks. Figures to the right indicate full marks.
SECTION I
Q.1
Define the pharmaceutical terms of the following.
07
Cardiovascular drugs
Anti-neoplastic
AIDS
Histamine
NSAID
Prodrugs
Antiarrhythmic drugs
Predict the product(s) of the following reactions:
SECTION II
Q.2
What are antibiotics? Explain the synthesis and uses of following antibiotics:
07
Ampiciline
Cephalexin
What are anti-tubercular drugs? Explain the synthesis and mechanism of action of following anti-tubercular drugs.
07
Isoniazide
Ethambutol
Q.3
Discuss the various synthesis methods of procaine and mechanism of nerve impulse transmission in action of Local anaesthetics.
07
What are antimalarials? Give the synthesis and mechanism of action of trimethoprim.
07
Q.4
What are analgesic and antipyretic drugs? Discuss the synthesis, applications and adverse effects of the following drugs.
07
Paracetamol
Meperidine
Explain the synthesis, applications and side effects of following anti-Inflammatory drugs (any
07
Dichlorophenac
Indomethacin
Arachidonic acid
SECTION III
Q.5
Explain the synthesis of benzofuran from coumarin. What is the action of following on benzofuran:
05
Cl2/ CS2
DMF/ POCl3
Ac2O
Explain the cyclization of open chain to aziridine ring is stereo specific. What is the reaction of following on aziridine:
05
HCl
CH3COCl
Vinyl cyanide
Synthesis of coumarin and chromones.
04
Q.6
Explain synthesis of oxazole derivatives from acyl-amino ketones, esters and amides with suitable example.
05
Write various synthesis methods of quinoline and isoquinolines.
05
Explain Fisher- Indole synthesis with mechanism.
04
Q.7
Write notes on any three of the following:-
14
Pyridazine
Purines
Quinoxalines
Pyrazoles
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