Master of Science II (Microbiology) Examination: Oct/Nov 2016
Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR S0
633
Wednesday
23/11/2016
02.30 PM
to
05.00 PM
Bioinformatics
Biometry
C
XII
Instructions: Part I. Q.1 is compulsory
Attempt any 4 questions from part II
Figures to the right indicated full marks
Answer to the part I and part II are to be written in same
answer booklet only.
Total Marks: 70
PART 1
Q.1 Rewrite the sentences by choosing correct alternatives from the following 14
The fundamental statistical indicators are
Mean standard deviation Median
Variance Mode
The median of a series of numerical values is
Equal to the average A graph or hart
A number A frequency table
is a measure of central tendency which is least affected by
extreme values
Mean Mode
H.M Median
The term used to refer something "performed on computer or computer
simulation" is
Dry lab Wet lab
In vitro In silico
The alignment procedure that tries to align the entire sequence is
Multiple sequence alignment Pair wise alignment
Global alignment Local alignment
If a series of values consist of 21 numbers, then for finding the median, we
ordered the series ascending and we use
The 11th value in the ordered
series
The mean between the 10th
and 11th values
The mean between the 11th
and 12th values
The 10 th value in the
ordered series
A clinical trial is more valuable when
Sensitivity and specificity
have higher values
Sensitivity is higher than
specificity
Specificity is higher than
sensitivity
The sensitivity specificity
values are regardless of their
values
The result of a statistical test, denoted shall be interpreted as follows:
The null hypothesis H0 is
rejected If p <0.05
The null hypothesis I H0 is
rejected if p >0.05
The alternate hypothesis H1
is rejected if p 0.05
The null hypothesis is H0 is
accepted if p >0.05
Which of the following is a sequence alignment tool
BLAST PRINT
PROSITE PIR u
10) The comprehensive database for the study of human genetics and molecular
biology is
PDB STAG
OMIM PSD
11) FlyBase is a
Biodiversity database Model organism database
Literature database Biomolecular database
12) is study of association between genome data and drug response
platforms
Pharmainformatics Pharmaproteomics
Pharmacogenomics Pharmacopeia
13) The database covered by Entrezfor probeset is
Gene expression omnibus Swis PROT
PubMED DBCET
14) Is the branching graph used to represent eg phylogenetic relationships or
the clustering of microarray data.
Microdendogram Cladogram
Phylogram Dendrogram
PART II
Q.2 Write in detail on standard deviation and give its applications with example. 14
Q.3 What is phylogeny? Discuss various algorithms used in phylogenetic analysis. 14
Q.4 Write a short note on any two of the following 14
Describe in detail large scale genome sequencing strategies.
Briefly describe pharmacogenomics.
Explain in detail descriptive statistics.
Q.5 Write short answers (any two) 14
Application of bioinformatics and drug discovery.
Briefly describe multiple comparison test.
Describe in detail prediction of 3D protein structure.
Q.6 Write short notes on (any two) 14
Describe in detail chi-square test.
Briefly describe frequency distribution with example.
Describe in detail Swiss PROT.