Master of Science II (Genetics) Examination: Oct /Nov 2016
Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR SQ
460
Friday
18/11/2016
02:30 PM
to
05:00 PM
Cancer Genetics and Stem
Cell Research
C
X
Instructions: Section I is compulsory
From section II attempt any four
All questions carry equal marks
Figures to right indicate full marks.
Draw neat and labeled diagrams.
Total Marks: 70
Section I
Q.1 Rewrite the following sentences by using correct alternative. 07
act like a spool that DNA can be wound around to become
more compact.
Histone Nuclease
Protease Helicase
Hematopoietic stem cells are cell
Unipotant Totipotant
Pluripotant Embryonic
Regulation of epithelial and mesennchymal interactions is carried out by
Platelet Derived Growth Factor Goblet growth factor
Zymogenic factor Tumor Necrotic factor
The ability to invade surrounding tissue and is main hallmark of
cancer.
Regeneration Replication
Metastasis Motility
The protease system involved in apoptosis pathway is called as
Caspases CD molecules
P53 TGF-B
are totipotant cells.
Mesenchymal stem cells Hematopoietic stem cells
Liver stem cells Embryonic stem cells
The underlying principle of is to kill cancer cells or stop them
growing by treating them with drugs.
Immunotherapy Hormone therapy
Chemotherapy Gene therapy
Answer the following terms: 07
Epigenetics
Oncogene
Embryonic stem cell.
Benign tumor
Hematopoietic Stem Cells
Carcinogens
Extra Cellular Matrices
Section II
(Attempt any four)
Q.2 Discuss in detail Tumor suppressor gene. 14
Q.3 Explain in detail isolation of stem cells from tissue. 14
Q.4 Explain in detail event of angiogenesis. 14
Q.5 Answer any two of the following 14
Write on Mesenchymal Stem Cells.
Give details mechanism of Metastatic cascade.
Discuss Radiation Therapy.
Q.6 Answer any two of the following 14
Write a short note on Transplantation Technique.
Explain Epigenetic in cancer.
Add a note on physical carcinogens.