M.Sc. (Semester IV) (CBCS) Examination Nov/Dec-2018
Genetics
CANCER GENETICS AND STEM CELL RESEARCH
Time: 2½ Hours Max. Marks: 70
Instructions: Section I is compulsory.
Attempt any four questions from Section II
All questions carry equal marks.
Draw neat and labeled diagrams wherever necessary.
Section I
Q.1 Rewrite the sentence after choosing correct answer from the given
alternatives:
07
The P53 protein normally promotes
DNA repair Tumor formation
Cell division Apoptosis
Which of the following is characteristic of a malignant rather than a
benign tumour?
Undergoes metastasis
Develops a blood supply
Cells divide an unlimited number of times
Grows without needing a growth signal
Which of the following statements about the Rb tumour suppressor
protein is correct?
Rb is activated when phosphorylated by Cd
Rb binds the transcription factor E2F and thus prevents the cell
from entering S phase until a mitogenic signal is received
Rb is a transcription factor
When a mitogenic signal is received, Rb binds the transcription
factor E2F and thus stimulates the cell to enter S phase
Which cellular organelles are involved in the initiation of the intrinsic
pathway of apoptosis?
Endoplasmic reticulum Lysosomes
Mitochondria Peroxisomes
Organ culture can be performed using
Raft method Plasma clot method
Grid method All of these
The first successfully cloned animal was
Rabbit Sheep
Rat Dog
The method in which the nucleus of a donor cell is relocated to an
enucleated target cell is known as
Cell transformation Nuclear transplantation
Organ transplant All of these
Page 2 of 2
SLR-VK-320
Q.1 Define the following terms. 07
Carcinogene
Epigenetics
Oncogene
Stem cells
Radiation therapy
Metastasis
Angiogenesis
Section II
Answer any four of the following:
Q.2 Describe extrinsic and intrinsic pathways of apoptosis with suitable diagram. 14
Q.3 Explain in detail immunotherapy for cancer. 14
Q.4 Describe in detail mechanism of Regeneration of Bone and Cartilage. 14
Q.5 Answer any Two of the following:
Add a note on P53 gene
Write a note on Metastasis.
Write a note on Organ Culture.
14
Q.6 Answer any Two of the following: 14
Write a note on trypsinization of tissue.
Write a note on embryonic stem cell.
Describe cell cycle.