Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER III • EXAMINATION WINTER • 2016
Subject Code: 230002 Date: 21-11-2016
Subject Name: Pharmaceutical Engineering II
Time: 02:30 pm 05:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

How will you determine flow property of a given powder sample?
06

What are the measures to alter flow property of a given sample?
05

How does a reposograph help determine dosage form suitability?
05
Q.2

Define "content uniformity". Explain in details its importance in pharmaceutical dosage form.
06

Briefly discuss "means of content uniformity achievement".
05

What are the techniques of sampling for content uniformity?
05
Q.3

What are the elements of control chart?
06

Enumerate different types of charts. Explain anyone in details.
05

What is the importance of control charts in pharmaceutical processings.
05
Q.4

Explain the concept of supercritical fluids.
06

What is Rapid Expansion of Supercritical Solution (RESS) technique?
05

Explain various processes and equipments used in supercritical fluid application.
05
Q.5

What do you understand by pellets. Give factors affecting pellet properties.
06

Explain different types of extrusion processes and techniques for spheronization.
05

Discuss the various excipients used in pelletization techniques.
05
Q. 6

Write a note on requirements of regulatory agencies USP, EP) for content uniformity.
06

Write a note on particle size and particle size distribution.
05

Explain Carr's Index Compressibility index and give the pharmacopoeial specifications for it.
05
Q.7

What is the significance of addition of glidants lubricants anti-adherents?
06

Write a note on "shape transition during spheronization".
05

What are the advantages and limitations of Carbon dioxide as SCF?
05