Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 230002 Date: 06/12/2018
Subject Name: Pharmaceutical Engineering II
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define content uniformity. Discuss its importance in pharmaceutical dosage forms.
06

Describe factors affecting achieving content uniformity.
05

Discuss error occur in control chart.
05
Q.2

Enumerate different types of charts. Explain any one in details.
06

Write a note on elements of control charts.
05

Write a note on requirements of regulatory agencies USP and EP) for content uniformity.
05
Q.3

What is importance of powder flow? Discuss factor influencing on powder flow.
06

Explain the various methods for measurement of angle of repose.
05

What are the pharmacopoeial specifications for Carr's index, Hausner's ratio and angle of repose?
05
Q.4

Discuss factors affecting pellet properties.
06

Enlist methods of extrusion. Write a note on Hot Melt Extrusion.
05

Explain spheronization. Discuss in brief stages involved in spheronization process.
05
Q.5

Write a note on SAS technology.
06

Draw and explain phase diagram shows supercritical region with examples.
05

What are the advantages and limitations of Carbon dioxide as SCF?
05
Q. 6

What are pellets? Write their pharmaceutical application and properties.
06

Differentiate inclusion complex and solid dispersion.
05

Describe the role of microcrystalline cellulose in pelletization.
05
Q.7

Explain the application of supercritical fluid in pharmacy.
06

Explain various processes and equipments used in supercritical fluid application.
05

Write a note on Rapid Expansion of Supercritical Solution (RESS) technique.
05