Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy SEMESTER- III EXAMINATION WINTER 2016
Subject Code: 230001 Date:17/11/2016
Subject Name: Physical Pharmaceutics II
Time: 2:30 PM to 5:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

State Raoult's law. Explain in details about positive and negative deviations
from Raoult's law.
06

Write applications of protein binding.
05

Write Pharmaceutical applications of polymers
05
Q.2

Classify organic molecular complexes. Describe drug and caffeine Complexes.
06

Describe the type-I dissolution apparatus with labeled diagram
05

What are the limitations of accelerated stability studies?
05
Q.3

Explain Noyes-Whitney's equation for the rate of dissolution
06

Describe the Beckmann method to determine freezing point lowering
05

Explain kinetic of protein binding.
05
Q.4

Explain in brief 'First-Order' and pseudo first order reactions.
06

Describe Ostwald-Walker method of measuring the relative lowering of vapour pressure.
05

Write short note on "chelates".
05
Q.5

State and explain Fick`s second law of diffusion. Write its Applications
06

Explain Electrolytes, Coulomb, Ampere, Ohm, Volt
05

Explain methods for determination of protein binding.
05
Q. 6

Enumerate the factors affecting the reaction rates and discuss the influence of temperature in brief
06

Describe the method for studying in vitro drug diffusion.
05

Explain in brief, (1)The L value Osmolality
05
Q.7

Discuss Steady-State Diffusion.
06

Discuss in brief properties of solutions of electrolytes
05

Discuss Dissolution and Disintegration of drug from solid dosage forms
05