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Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER- III • EXAMINATION SUMMER 2017
Subject code: 230001 Date: 26/05/2017
Subject Name: Physical Pharmaceutics-II
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss Pharmaceutical applications of polymers in brief with suitable examples
06

Enumerate methods to determine the molecular weight of polymers. Describe the equations to determine the different molecular weights and polydispersity of polymers
05

Define the following terms with reference to polymers:
1. Homo polymer
2. Graft copolymer
3. Cross linked polymer
4. Isotactic polymer
5. Dendrimers
05
Q.2

Define: Flux. Describe Fick's First law of diffusion and discuss its application. What is steady state diffusion?
06

Define Diffusion and describe with relevant examples its applications in Pharmacy
05

Define dissolution .What is the importance of dissolution for Pharmaceutical dosage forms? Explain the Noyes Whitney equation for describing rate of drug dissolution.
05
Q.3

Define: Rate and Order of reaction. Describe the equation for zero order kinetics. How is the half life and shelf life determined for a zero order reaction?
06

Explain the pathways of drug degradation in brief.
05

Explain the influence of temperature on rate of drug degradation
05
Q.4

What are the different types of complexes? Describe in brief chelates and their properties
06

What is the significance of Protein Binding of drugs?
05

Explain the Arrhenius theory of electrolytic dissociation.
05
Q.5

An aqueous solution of exsiccated ferrous sulfate was prepared by adding 41.50 g of FeSO4 to enough water to make 1000 mL of solution at 18°C. The density of the solution is 1.0375g/ml and the molecular weight of FeSO4 is 151.9. Calculate the molarity; the molality; the mole fraction of FeSO4, the mole fraction of water, and the mole percent of the two constituents; and the percentage by weight of FeSO4.
06
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What are colligative properties? Describe any two colligative properties of nonelectrolytes in solution.
05

What is the difference between Osmolarity and Osmolality? How is osmotic coefficient calculated?
05
Q. 6

Explain the methods to determine molecular weight using colligative properties.
06

Enumerate important properties of electrolyte solutions.
05

Define: Drug release. How are dosage forms classified based on drug release?
05
Q. 7

Explain the method to study dissolution using Paddle Apparatus.
06

What is accelerated stability testing? How is the expiry date of a product determined?
05

The measured conductance of a 0.1 N solution of a drug is 0.0563 ohm at 25°C. The cell constant at 25°C is 0.520 cm-1. What is the specific conductance and what is the equivalent conductance of the solution at this concentration?
05