Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPC103T Date: 05/01/2019
Subject Name: Advanced Medicinal Chemistry
Time :10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Enumerate stages of drug discovery and explain methods of lead discovery.
06

Explain the theories involved in drug receptor interaction.
05

Why we required lead optimization? Explain methods involved in lead optimization.
05
Q.2

Add a note on rational behind prodrug design.
06

Explain strategies to combat drug resistance in antibiotics therapy.
05

Why is cancer so difficult to cure? Explain with drug resistance.
05
Q.3

Why analog design important in drug design? Explain any one strategy involved in analog design.
06

Write recent advancement in anticancer agents.
05

Why stereochemistry is important in drug action?
05
Q.4

Explain the strategies involved in development antiviral agents.
06

Explain enzyme kinetics principles of enzyme inhibitors.
05

Add a note on enzyme inhibitors in basic research.
05
Q.5

Explain design of peptidomimetics.
06

Explain chemistry of prostaglandins, leukotrienes and thromboxanes.
05

Add a note on identification, validation and diversity of drug targets.
05
Q. 6

Explain latest development of antihypertensive medication.
06

Add a note on carrier linked prodrugs.
05

Explain simplification approach in lead optimization
05
Q.7

Explain non-covalently and covalently binding enzyme inhibitors.
06

Add a note on COX-1 COX-2 inhibitors.
05

Explain H1 H2 receptor antagonists.
05