Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharm SEMESTER III EXAMINATION WINTER -2017
Subject Code: 930101 Date: 10/11/2017
Subject Name: Advanced Medicinal Chemistry
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What are different synthetic approaches used in combinatorial chemistry. Discuss their applications.
10

Write note on various immunosuppressants
06
Q.2

Discuss chemistry and SAR of angiotensin receptor blockers
08

Discuss chemistry and SAR of glucocorticoids and recently developed glucocorticoids
08
Q.3

Discuss SAR of tetracyclines and recently discovered tetracyclines
06

Discuss about various HIV protease inhibitors
05

Write detailed note on mineralocorticoids
05
Q.4

How resistance is devloped in bacteria? What are the different methods of treatment used to overcome it? Classify antibiotics. Outline synthyetic route of sparfloxacin.
08

Explain in detail rationale behind application of microorganisms for drug synthesis with suitable examples. What are merits and demerits of this technique?
08
Q.5

Discuss about development and fate of COX-2 inhibitors. What are alternate targets for NSAIDS?
08

Enlist different neurodegenerative diseases? Discuss on diseases you have studied with recent advances in their therapy.
08
Q. 6

Which are the different methods used for synthesis of peptides? Discuss about method developed by Bruce Merrifield. Why peptides are useful as drugs? What are their pitfalls?
10

Discuss enzyme immobilization techniques
06
Q.7

Give detailed account on recent advances in the therapy of following diseases with their merits and demerits.
Tuberculosis
06

Allergy
05

Diabetes (type I II)
05