Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER- 7 EXAMINATION SUMMER -2019
Subject Code: 2270001 Date: 06-05-2019
Subject Name: Dosage form Design I
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define preformulation. Write a note on physicochemical properties related to solubility study in preformulation.
06

Explain effect of pKa and pH on absorption parameter.
05

Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
05
Q.2

Explain world climatic zones as per ICH guidelines.
06

Discuss the effect of containers and closures on stability of pharmaceuticals.
05

What do you understand by prodrug? Give its applications for improving stability of drug.
05
Q.3

Enlist factors affecting gastro intestinal absorption. Discus in detail effect of gastric empting time on drug absorption.
06

Write a short note on kinetics of protein-drug binding
05

Discuss Matrixing and Bracketing Techniques
05
Q.4

What do you understand by first pass metabolism? How would you avoid it?
06

Write a note on similarity factor and dissimilarity factor.
05

Enlist the theories of dissolution. Explain in detail Film Theory.
05
Q.5

"Hydrophylicity and lipophylicity property of a drug decide its absorption"
Comment with justification.
06

Write a note on pharmaceutical excipients used as tablet binder and granulating agent.
05

Explain various methods used for enhancement of bioavailability.
05
Q. 6

Discuss the regulatory requirements for conduction of bio-equivalence studies.
06

Write a note on volume of distribution.
05

Explain renal clearance.
05
Q.7

Classify the polymers. Discuss in brief about polymer properties.
06

Write a note on Biodegradable polymers.
05

Enlist the cellulosic derivative polymers and discuss its Phthalate derivatives.
05