Exam Details
| Subject | dosage form design- i | |
| Paper | ||
| Exam / Course | b.pharm | |
| Department | ||
| Organization | Gujarat Technological University | |
| Position | ||
| Exam Date | May, 2017 | |
| City, State | gujarat, ahmedabad |
Question Paper
Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM.-SEMESTER-VII- EXAMINATION -SUMMER-2017
Subject Code: 270001 Date: 27/04/2017
Subject Name: Dosage Form Design- I
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Discuss effect of pKa of drug on absorption of drug from GIT at different pH.
06
Write a note on Polymorphism giving examples.
05
Explain mutual prodrugs. Describe the prodrug design for improvement of stability and bioavailability giving suitable examples.
05
Q.2
Discuss different approaches for prevention of chemical degradation of pharmaceuticals.
06
Define Mean Kinetic Temperature (MKT). Discuss different climatic zones for stability studies.
05
What are temperature and humidity requirements for performing stability study according to ICH guideline?
05
Q.3
Write brief note on factors affecting plasma protein binding.
06
Why overages are added in formulation? How it can be calculated?
05
Discuss physiological barriers for distribution of drugs.
05
Q.4
Define biopharmaceutics and give its role in dosage form desing.
06
Enumerate different types of transport mechanism. Explain active transport in detail.
05
Define gastric empting and explain factors affecting gastric empting.
05
Q.5
Write detail note on organoleptic additives.
06
Classify stabilizers and write their pharmaceutical applications.
05
Classify suspending agents. What are ideal characteristics of suspending agent?
05
Q. 6
Enlist methods of dissolution profile comparison Discuss in detail model independent method.
06
What is BCS? How BCS class of a drug is decided?
05
Define Intrinsic dissolution rate. Discuss factors affecting rate of dissolution.
05
Q.7
What are the objectives of bioavailability study? Explain measurement of bioavailability by Plasma level-time study.
06
What is therapeutic equivalence? Enlist various in-vivo and in-vitro approaches that can be utilized to establish bioequivalence.
05
Differentiate absolute and relative bioavailability. What are the acceptance criteria for bioequivalence study?
05
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM.-SEMESTER-VII- EXAMINATION -SUMMER-2017
Subject Code: 270001 Date: 27/04/2017
Subject Name: Dosage Form Design- I
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Discuss effect of pKa of drug on absorption of drug from GIT at different pH.
06
Write a note on Polymorphism giving examples.
05
Explain mutual prodrugs. Describe the prodrug design for improvement of stability and bioavailability giving suitable examples.
05
Q.2
Discuss different approaches for prevention of chemical degradation of pharmaceuticals.
06
Define Mean Kinetic Temperature (MKT). Discuss different climatic zones for stability studies.
05
What are temperature and humidity requirements for performing stability study according to ICH guideline?
05
Q.3
Write brief note on factors affecting plasma protein binding.
06
Why overages are added in formulation? How it can be calculated?
05
Discuss physiological barriers for distribution of drugs.
05
Q.4
Define biopharmaceutics and give its role in dosage form desing.
06
Enumerate different types of transport mechanism. Explain active transport in detail.
05
Define gastric empting and explain factors affecting gastric empting.
05
Q.5
Write detail note on organoleptic additives.
06
Classify stabilizers and write their pharmaceutical applications.
05
Classify suspending agents. What are ideal characteristics of suspending agent?
05
Q. 6
Enlist methods of dissolution profile comparison Discuss in detail model independent method.
06
What is BCS? How BCS class of a drug is decided?
05
Define Intrinsic dissolution rate. Discuss factors affecting rate of dissolution.
05
Q.7
What are the objectives of bioavailability study? Explain measurement of bioavailability by Plasma level-time study.
06
What is therapeutic equivalence? Enlist various in-vivo and in-vitro approaches that can be utilized to establish bioequivalence.
05
Differentiate absolute and relative bioavailability. What are the acceptance criteria for bioequivalence study?
05
Subjects
- agronomy and forestry of medicinal plants
- anatomy physiology & health education -ii
- anatomy, physiology and health education (aphe)
- applied mathematics (biostatistics)
- basic computer applications
- basic concepts of pharmacology and clinical pharmacy practice
- basics of computer applications
- bioavailability & therapeutic drug monitoring
- bioavailability and therapeutic drug monitoring
- biochemistry
- clinical pharmacy ii
- clinical pharmacy-i
- commerce of herbs and phytoconstitutents
- computer applications in drug discovery
- current advances in novel drug delivery systems
- cyber security
- disaster management
- dispensing pharmacy i
- dispensing pharmacy i and drug store management
- dispensing pharmacy ii and pharma industrial management
- dosage form design –i
- dosage form design- i
- dosage form design- ii
- dosage form design-i
- dosage form design-ii
- drug approval process
- environmental studies
- environmental toxicology and green audit
- food analysis
- forensic pharmacy
- forensic pharmacy-i
- genetic engineering and gene therapy
- green chemistry
- health education and community health
- herbal cosmetics
- hospital and community pharmacy
- hospital management and medical tourism
- hospital pharmacy, community pharmacy & forensic pharmacy
- hospital pharmacy, community pharmacy and dispensing pharmacy-ii
- human anatomy physiology
- human anatomy physiology and health education-ii
- human anatomy physiology-ii
- human anatomy, physiology and health education - i
- innovations in conventional drug delivery system
- instrumental and process validation
- intellectual property rights and patents
- medical writing and coding
- medicinal biochemistry
- nutraceuticals
- pathophysiology
- pharmaceutical analysis ii
- pharmaceutical analysis iii
- pharmaceutical analysis iv
- pharmaceutical analysis-i
- pharmaceutical analysis-ii
- pharmaceutical analysis-iv
- pharmaceutical chemistry – ii
- pharmaceutical chemistry – vi (organic chemistry – ii)
- pharmaceutical chemistry –viii (medicinal chemistry - ii)
- pharmaceutical chemistry iii
- pharmaceutical chemistry iv
- pharmaceutical chemistry vii
- pharmaceutical chemistry-i
- pharmaceutical chemistry-i (inorganic chemistry)
- pharmaceutical chemistry-ii (physical chemistry)
- pharmaceutical chemistry-iii (biochemistry – i)
- pharmaceutical chemistry-iv (organic chemistry-i)
- pharmaceutical chemistry-ix (medicinal chemistry-iii)
- pharmaceutical chemistry-v
- pharmaceutical chemistry-v (biochemistry-ii)
- pharmaceutical chemistry-vi (medicinal)
- pharmaceutical chemistry-vii
- pharmaceutical chemistry-viii
- pharmaceutical chemistry-x
- pharmaceutical chemistry-x (medicinal chemistry-iii)
- pharmaceutical engineering
- pharmaceutical engineering-ii
- pharmaceutical inorganic chemistry
- pharmaceutical marketing management
- pharmaceutical microbiology - i
- pharmaceutical microbiology & biotechnology i
- pharmaceutical microbiology &biotechnology- ii
- pharmaceutical microbiology and biotechnology - ii
- pharmaceutical organic chemistry
- pharmaceutical technology - i
- pharmaceutical technology – i
- pharmaceutical technology- ii
- pharmaceutical technology-i
- pharmaceutical technology-ii
- pharmaceutics-i
- pharmaceutics-ii
- pharmaceutivcal chemistry ix
- pharmacognosy iii
- pharmacognosy iv
- pharmacognosy vi
- pharmacognosy vii
- pharmacognosy vii (herbal formulations & complimentary therapies)
- pharmacognosy-i
- pharmacognosy-ii
- pharmacognosy-iii
- pharmacognosy-iv
- pharmacognosy-v
- pharmacognosy-v (plant bio technology)
- pharmacognosy-vi
- pharmacology -iii
- pharmacology & pharmacotherapeutics-ii
- pharmacology and pharmacotherapeutics - i
- pharmacology and pharmacotherapeutics - iii
- pharmacology and pharmacotherapeutics-iv
- pharmacology-i
- pharmacology-ii
- pharmacovigilance
- pharmacy practice
- physical pharmaceutics-ii
- physical pharmacy
- quality by design (qbd) and process analytical technology (pat)
- regulatory aspects of food and neutraceuticals
- remedial mathematics
- unit operation - i
- unit operation - ii