Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER- 6 EXAMINATION SUMMER -2019
Subject Code: 2260003 Date: 08-05-2019
Subject Name: Pharmaceutical Analysis IV
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain Bragg's law and write a note on different method for x-ray diffraction study.
06

Write a note on GLP.
05

Explain the Principle of Ion exchange and Super critical Fluid chromatography.
05
Q.2

Explain the Principle of Gas Chromatography. Enlist the detectors used in GC and explain any one.
06

Explain the Various steps involved in Patent filling.
05

Give the application of X-ray diffraction study.
05
Q.3

Discuss the Principle and application of HPLC.
06

Write a note on Raman spectroscopy.
05

Give an overview of LC-MS/MS.
05
Q.4

Write a short note on Affinity chromatography.
06

Give a brief note on GC-MS.
05

Write a note on ISO 9001:2000.
05
Q.5

Write a note on RIA.
06

Give brief idea about HETP, Peak asymmetry factor, Resolution.
05

Write a note on GATT and TRIPS.
05
Q. 6

Discuss in detail on HPLC instrumentation.
06

Explain principle, methodology and application of ELISA.
05

Write a note on Isotope dilution analysis.
05
Q.7

Discuss the Principle and Instrumentation of HPTLC.
06

Write a note on Neutron Activation Analysis.
05

Enlist the parameters for Analytical Method Validation as per ICH guidelines and discuss on Accuracy and Precision.
05